MAML3 抗体
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- 抗原 See all MAML3 抗体
- MAML3 (Mastermind-Like 3 (MAML3))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MAML3 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Purified
- 纯度
- Protein G affinity chromatography
- 免疫原
- A human full length recombinant protein was used as the immunogen for this MAML3 antibody.
- 克隆位点
- MAML3-1303
- 亚型
- IgG1
- Top Product
- Discover our top product MAML3 Primary Antibody
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anti-Mastermind-Like 3 (MAML3) antibody
MAML3 适用: 人 ISt, IHC, StM 宿主: 小鼠 Monoclonal MAML3-1303 unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 1024-1131) antibodyMAML3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 640-665), (C-Term) antibodyMAML3 适用: 人 FACS, WB, IHC (p) 宿主: 兔 Polyclonal RB18761 unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 FACS, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 791-840) antibodyMAML3 适用: 人, 小鼠, 马, 兔, 犬, 豚鼠, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal MAML3-1303 unconjugated
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- 应用备注
- The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MAML3 antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells,Immunofluorescence: 1-2 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL
- 限制
- 仅限研究用
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- 缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
- 储存液
- Azide free
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store the MAML3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- 抗原
- MAML3 (Mastermind-Like 3 (MAML3))
- 别名
- MAML3 (MAML3 产品)
- 别名
- AV234550 antibody, BC049812 antibody, Mam-2 antibody, mKIAA1816 antibody, Glrp1 antibody, CAGH3 antibody, ERDA3 antibody, GDN antibody, MAM-2 antibody, MAM2 antibody, TNRC3 antibody, mastermind like 3 (Drosophila) antibody, mastermind-like transcriptional coactivator 3 antibody, mastermind like transcriptional coactivator 3 antibody, Maml3 antibody, MAML3 antibody
- 背景
- Mastermind-like 3 is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch 1-4 proteins. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, its upregulation is thought to be involved in oncogenesis.
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