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RWDD3 抗体

RWDD3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5701924
发货至: 中国
  • 抗原 See all RWDD3 抗体
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    适用
    • 23
    • 8
    • 7
    • 2
    • 1
    宿主
    • 22
    • 1
    克隆类型
    • 23
    多克隆
    标记
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    This RWDD3 antibody is un-conjugated
    应用范围
    • 22
    • 17
    • 15
    • 11
    • 2
    • 2
    ELISA, Immunohistochemistry (IHC)
    免疫原
    RWD domain containing 3
    亚型
    IgG
    Top Product
    Discover our top product RWDD3 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze / thaw cycles.
    储存条件
    -20 °C
    有效期
    12 months
  • 抗原
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    别名
    RWDD3 (RWDD3 产品)
    别名
    DKFZp469N1913 antibody, RSUME antibody, 2510027J23Rik antibody, 3110037C01Rik antibody, AI035684 antibody, AI662458 antibody, X2CR1 antibody, X2cr1 antibody, zgc:73229 antibody, RWD domain containing 3 antibody, RWDD3 antibody, rwdd3 antibody, Rwdd3 antibody
    背景
    Synonyms:RSUME Background:Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha(NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha(HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.
    基因ID
    25950
    UniProt
    Q9Y3V2
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