电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

USP28 抗体

USP28 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5701387
发货至: 中国
  • 抗原 See all USP28 抗体
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    适用
    • 48
    • 17
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 60
    • 2
    • 1
    克隆类型
    • 62
    • 1
    多克隆
    标记
    • 20
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This USP28 antibody is un-conjugated
    应用范围
    • 39
    • 26
    • 13
    • 13
    • 13
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    免疫原
    ubiquitin specific peptidase 28
    亚型
    IgG
    Top Product
    Discover our top product USP28 Primary Antibody
  • 应用备注
    WB : 1:500-1:5000,IP:1:200-1:2000,IHC:1:20-1:200
    说明

    HeLa cells were subjected to SDS PAGE followed by western blot with FNab09322(USP28 antibody) at dilution of 1:1000

    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze / thaw cycles.
    储存条件
    -20 °C
    有效期
    12 months
  • 抗原
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    别名
    USP28 (USP28 产品)
    别名
    im:7138195 antibody, USP28 antibody, 9830148O20Rik antibody, AU022237 antibody, mKIAA1515 antibody, ubiquitin specific peptidase 28 antibody, USP28 antibody, usp28 antibody, Usp28 antibody
    背景
    Synonyms:Deubiquitinating enzyme 28, KIAA1515, Ubiquitin thiolesterase 28, USP28 Background:Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome(APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7(FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7(FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes(TSGs) in a subset of colorectal cancers(CRC) cells(PubMed:24623306).
    分子量
    125kDa
    基因ID
    57646
    UniProt
    Q96RU2
You are here:
客服