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DIRAS3 抗体 (C-Term)

DIRAS3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5689944
发货至: 中国
  • 抗原 See all DIRAS3 抗体
    DIRAS3 (DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3))
    抗原表位
    • 2
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    C-Term
    适用
    • 23
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    宿主
    • 20
    • 3
    克隆类型
    • 21
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    多克隆
    标记
    • 11
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    This DIRAS3 antibody is un-conjugated
    应用范围
    • 14
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    • 2
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    Western Blotting (WB), ELISA
    特异性
    DIRAS3 antibody is human specific.
    纯化方法
    DIRAS3 antibody is affinity chromatography purified via peptide column.
    免疫原
    DIRAS3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DIRAS3.

    The immunogen is located within the last 50 amino acids of DIRAS3.
    亚型
    IgG
    Top Product
    Discover our top product DIRAS3 Primary Antibody
  • 应用备注
    DIRAS3 antibody can be used for detection of DIRAS3 by Western blot at 1 - 2 μ,g/mL.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    DIRAS3 antibody is supplied in PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    DIRAS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • 抗原
    DIRAS3 (DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3))
    别名
    DIRAS3 (DIRAS3 产品)
    别名
    DIRAS3 antibody, arhi antibody, noey2 antibody, ARHI antibody, NOEY2 antibody, DIRAS family GTPase 3 antibody, DIRAS family GTP binding RAS like 3 antibody, DIRAS3 antibody, diras3 antibody
    背景
    DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3).
    分子量
    Predicted: 25 kDa

    Observed: 24 kDa
    基因ID
    9077
    NCBI登录号
    NP_004666
    UniProt
    O95661
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