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CERS6 抗体 (AA 62-131)

CERS6 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
产品编号 ABIN566978
发货至: 中国
  • 抗原 See all CERS6 抗体
    CERS6 (Ceramide Synthase 6 (CERS6))
    抗原表位
    • 8
    • 7
    • 6
    • 5
    • 5
    • 2
    • 1
    AA 62-131
    适用
    • 35
    • 13
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 32
    • 3
    小鼠
    克隆类型
    • 32
    • 3
    多克隆
    标记
    • 14
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CERS6 antibody is un-conjugated
    应用范围
    • 24
    • 22
    • 4
    • 4
    • 2
    • 1
    ELISA, Western Blotting (WB)
    原理
    Mouse polyclonal antibody raised against a partial recombinant LASS6.
    序列
    PCAIALNIQA NGPQIAPPNA ILEKVFTAIT KHPDEKRLEG LSKQLDWDVR SIQRWFRQRR NQEKPSTLTR
    交叉反应
    产品特性
    Antibody Reactive Against Recombinant Protein.
    免疫原
    LASS6 (NP_982288, 62 a.a. ~ 131 a.a) partial recombinant protein with GST tag.
    Top Product
    Discover our top product CERS6 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    50 % glycerol
    注意事项
    Aliquot to avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Schüll, Günther, Brodesser, Seeger, Tosetti, Wiegmann, Pongratz, Diaz, Witt, Andree, Brinkmann, Krönke, Wiesner, Kashkar: "Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6." in: Cell death & disease, Vol. 6, pp. e1691, (2015) (PubMed).

    Cheng, Bai, Beckham, Marrison, Yount, Young, Lu, Bartlett, Wu, Keane, Armeson, Marshall, Keane, Smith, Jones, Drake, Bielawska, Norris, Liu: "Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse." in: The Journal of clinical investigation, Vol. 123, Issue 10, pp. 4344-58, (2013) (PubMed).

    Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells." in: Anticancer research, Vol. 32, Issue 3, pp. 753-60, (2012) (PubMed).

    Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy." in: Anticancer research, Vol. 32, Issue 7, pp. 2479-85, (2012) (PubMed).

    Senkal, Ponnusamy, Manevich, Meyers-Needham, Saddoughi, Mukhopadyay, Dent, Bielawski, Ogretmen et al.: "Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi ..." in: The Journal of biological chemistry, Vol. 286, Issue 49, pp. 42446-58, (2011) (PubMed).

    Senkal, Ponnusamy, Bielawski, Hannun, Ogretmen: "Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 1, pp. 296-308, (2010) (PubMed).

    White-Gilbertson, Mullen, Senkal, Lu, Ogretmen, Obeid, Voelkel-Johnson: "Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells." in: Oncogene, Vol. 28, Issue 8, pp. 1132-41, (2009) (PubMed).

    Senkal, Ponnusamy, Rossi, Bialewski, Sinha, Jiang, Jazwinski, Hannun, Ogretmen: "Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas." in: Molecular cancer therapeutics, Vol. 6, Issue 2, pp. 712-22, (2007) (PubMed).

    Yu, Novgorodov, Chudakova, Zhu, Bielawska, Bielawski, Obeid, Kindy, Gudz: "JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction." in: The Journal of biological chemistry, Vol. 282, Issue 35, pp. 25940-9, (2007) (PubMed).

  • 抗原
    CERS6 (Ceramide Synthase 6 (CERS6))
    别名
    LASS6 (CERS6 产品)
    别名
    si:ch211-278b7.1 antibody, CERS6 antibody, CERS5 antibody, LASS6 antibody, 4732462C07Rik antibody, AW544719 antibody, Lass6 antibody, T1L antibody, RGD1561599 antibody, ceramide synthase 6 antibody, CERS6 antibody, cers6 antibody, Cers6 antibody
    背景
    Full Gene Name: LAG1 homolog, ceramide synthase 6
    Synonyms: CerS6,MGC129949,MGC129950
    基因ID
    253782
    NCBI登录号
    NM_203463
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