Recombinant IL-6R (Tocilizumab Biosimilar) 抗体
适用: 人
ELISA, InhA
宿主: Human
Monoclonal
RhPM-1
unconjugated
Recombinant Antibody
(1 reference)-
- 抗原 See all IL-6R (Tocilizumab Biosimilar) products
- IL-6R (Tocilizumab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人
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宿主
-
Human
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克隆类型
- 单克隆
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标记
- This IL-6R (Tocilizumab Biosimilar) antibody is un-conjugated
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应用范围
- ELISA, Inhibition Assay (InhA)
- 特异性
- Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
- 产品特性
-
OriginalSpeciesName: Human
OriginalFormat: IgG1
- 纯化方法
- Purified antibody.
- 纯度
- > 98 % as determined by SDS-PAGE
- 内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- 免疫原
- This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
- 克隆位点
- RhPM-1
- 亚型
- IgG1 kappa
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anti-IL-6R (Tocilizumab Biosimilar) antibody
适用: 人 ELISA, InhA 宿主: 兔 Monoclonal RhPM-1 unconjugated Recombinant Antibody
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- 应用备注
- Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
- 说明
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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-
: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." in: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).
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: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." in: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).
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- 抗原
- IL-6R (Tocilizumab Biosimilar)
- Abstract
- IL-6R (Tocilizumab Biosimilar) 产品
- 别名
- CD126 antibody, IL-6R-1 antibody, IL-6RA antibody, IL6Q antibody, IL6RA antibody, IL6RQ antibody, gp80 antibody, interleukin 6 receptor antibody, IL6R antibody
- 物质类
- Biosimilar
- 背景
- IL6R, MRA, atlizumab
- UniProt
- A0N0L5
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