Recombinant CD22 (Epratuzumab Biosimilar) 抗体
适用: 人, Cynomolgus, 猕猴
FACS, BP, IP
宿主: 兔
Monoclonal
hL22
unconjugated
Recombinant Antibody
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- 抗原 See all CD22 (Epratuzumab Biosimilar) products
- CD22 (Epratuzumab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人, Cynomolgus, 猕猴
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This CD22 (Epratuzumab Biosimilar) antibody is un-conjugated
- 应用范围
- Flow Cytometry (FACS), Blocking Peptide (BP), Immunoprecipitation (IP)
- 特异性
- This antibody is specific for the 3rd Ig-like domain of human CD22 (epitope B), a cell surface glycoprotein present on mature B-cells and on many types of malignant B-cells.
- 产品特性
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OriginalSpeciesName: Human
OriginalFormat: IgG1
- 纯化方法
- Purified antibody.
- 纯度
- > 98 % as determined by SDS-PAGE
- 内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- 免疫原
- This antibody was prepared by the humanization of LL2 (EPB-2), a murine anti-CD22 IgG2a raised against Raji Burkitt lymphoma cells. Murine sequences comprise 5-10% of the molecule, with the remainder being human framework sequences, which greatly reduces the potential for immunogenicity (Traczewski, 2010).
- 克隆位点
- HL22
- 亚型
- IgG kappa
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- 应用备注
- Epratuzumab binds to the third extracellular domain of CD22, inducing CD22 phosphorylation, resulting in negative modulation of BCR activation, and rapid CD22 internalization, leading to modulation of B-cell homing (Traczewski, 2010). Initial phase II and two terminated early phase III studies suggest that the use of this antibody to treat systemic lupus erythematosus is effective and well tolerated, but both phase III trials failed to meet primary clinical efficacy endpoints. Additionally, in vitro studies and clinical trials indicate that this antibody can be used in combination therapy with another inhibitor of B-cell activity, rituximab (anti-CD20), in the treatment of non-Hodgkin lymphoma (Traczewski, 2010).
- 说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- CD22 (Epratuzumab Biosimilar)
- Abstract
- CD22 (Epratuzumab Biosimilar) 产品
- 别名
- SIGLEC-2 antibody, SIGLEC2 antibody, CD22 molecule antibody, CD22 antibody
- 物质类
- Biosimilar
- 背景
- Leu14, B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14
- UniProt
- P20273
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