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- 抗原 See all ALKBH7 抗体
- ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
- 抗原表位
- AA 1-221
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ALKBH7 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- MAGTGLLALR TLPGPSWVRG SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR YEYDHWDAAI HGFRETEKSR WSEASRAILQ RVQAAAFGPG QTLLSSVHVL DLEARGYIKP HVDSIKFCGA TIAGLSLLSP SVMRLVHTQE PGEWLELLLE PGSLYILRGS ARYDFSHEIL RDEESFFGER RIPRGRRISV ICRSLPEGMG PGESGQPPPA C
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1).
- 亚型
- IgG
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- 应用备注
- WB,1:200 - 1:2000
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
- 别名
- ALKBH7 (ALKBH7 产品)
- 别名
- ABH7 antibody, SPATA11 antibody, UNQ6002 antibody, 2310045B01Rik antibody, 2510008E23Rik antibody, Abh7 antibody, Spata11 antibody, alkB homolog 7 antibody, Alkbh7 antibody, ALKBH7 antibody
- 背景
- May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro, but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity.,ALKBH7,ABH7,SPATA11,UNQ6002,Epigenetics & Nuclear Signaling,DNA Damage & Repair,ALKBH7
- 分子量
- 24 kDa
- 基因ID
- 84266
- UniProt
- Q9BT30
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