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POLA1 抗体 (AA 1-33)

POLA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5646962
发货至: 中国
  • 抗原 See all POLA1 抗体
    POLA1 (DNA Polymerase alpha (POLA1))
    抗原表位
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-33
    适用
    • 32
    • 12
    • 11
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 39
    • 5
    • 1
    克隆类型
    • 41
    • 4
    多克隆
    标记
    • 21
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    This POLA1 antibody is un-conjugated
    应用范围
    • 20
    • 12
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    交叉反应 (详细)
    Expected species reactivity: Mouse,Rat
    纯化方法
    Antigen affinity purified
    免疫原
    A portion of amino acids 1-33 from human POLA1 was used as the immunogen for the DNA Polymerase alpha antibody.
    亚型
    Ig Fraction
    Top Product
    Discover our top product POLA1 Primary Antibody
  • 应用备注
    The stated application concentrations are suggested starting points. Titration of the DNA Polymerase alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. WB: 1:1000-1:2000
    限制
    仅限研究用
  • 缓冲液
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Aliquot the DNA Polymerase alpha antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原
    POLA1 (DNA Polymerase alpha (POLA1))
    别名
    DNA Polymerase alpha / POLA1 (POLA1 产品)
    别名
    pola antibody, AW321876 antibody, Pola antibody, POLA antibody, p180 antibody, polymerase (DNA directed), alpha 1, catalytic subunit S homeolog antibody, polymerase (DNA directed), alpha 1 antibody, DNA polymerase alpha 1, catalytic subunit antibody, pola1.S antibody, Pola1 antibody, POLA1 antibody
    背景
    Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes.
    UniProt
    P09884
    途径
    SARS-CoV-2 Protein Interactome
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