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- 抗原 See all FRMPD1 抗体
- FRMPD1 (FERM and PDZ Domain Containing 1 (FRMPD1))
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抗原表位
- C-Term
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FRMPD1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- FRMPD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human FRMPD1.
- 亚型
- IgG
- Top Product
- Discover our top product FRMPD1 Primary Antibody
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anti-FERM and PDZ Domain Containing 1 (FRMPD1) (AA 1-1578) antibody
FRMPD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
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ELISA. Western Blot: 1 - 2 μg/mL. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Store the antibody (in aliquots) at -20 °C.
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- 抗原
- FRMPD1 (FERM and PDZ Domain Containing 1 (FRMPD1))
- 别名
- FRMPD1 (FRMPD1 产品)
- 别名
- FRMD2 antibody, BC031840 antibody, mKIAA0967 antibody, FERM and PDZ domain containing 1 antibody, FRMPD1 antibody, Frmpd1 antibody
- 背景
- The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50 % and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.Synonyms: FERM and PDZ domain-containing protein 1, FERM domain-containing protein 2, FRMD2, KIAA0967
- 基因ID
- 22844
- NCBI登录号
- NP_055722
- UniProt
- Q5SYB0
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