PMS2 抗体 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae)) (AA 58-81)

Details for Product anti-PMS2 Antibody No. ABIN5550841, 供应商: Log in to see
抗原
  • HNPCC4
  • PMS2CL
  • PMSL2
  • AW555130
  • Pmsl2
  • PMS1 homolog 2, mismatch repair system component
  • PMS1 homolog2, mismatch repair system component
  • mismatch repair endonuclease PMS2
  • PMS2
  • Pms2
  • LOC463257
  • LOC107984056
抗原表位
AA 58-81
10
8
5
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
适用
Chimpanzee, Hamster, 人, 小鼠, 大鼠
123
41
18
2
2
2
1
1
1
1
1
1
1
1
宿主
小鼠
70
52
1
克隆类型 (克隆位点)
单克隆 ()
标记
This PMS2 antibody is un-conjugated
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
95
54
53
35
26
19
10
9
2
2
2
1
选项
Supplier
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免疫原 Recombinant human PMS2 corresponding to the first 133 amino acid residues of theprotein
克隆位点 349-29-5-2
亚型 IgG1
特异性 This antibody is directed against PMS2-134 and reacts with full length version of PMS2. The epitope was putatively mapped to amino acids 58-81 of human PMS2. Expect a band approximately 96 kDa in size corresponding to human PMS2 by western blotting in most cell lines and tissues as PMS2 is ubiquitously expressed.
交叉反应 (详细) Species reactivity (expected):Mouse, Rat, Chimpanzee (100 %)Species reactivity (tested):Human, Hamster
产品特性 Synonyms: PMSL2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2

Concentration: 1.38 mg/mL (by UV absorbance at 280 nm)
纯化方法 Protein chromatography
Plasmids, Primers & others Plasmids, Primers & others PMS2 products on genomics-online (e.g. as negative or positive controls)
抗原
别名 PMS2 (PMS2 Antibody 摘要)
背景 PMS2 is a highly conserved nuclear protein involved in mismatch repair during DNA replication and has been identified to be composed as a heterodimer of PMS2 and MLH1. PMS is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4), Turcot syndrome (an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas) and supratentorial primitive neuroectodermal tumors with cafe-au-lait spots (SNTCL). The human PMS2 gene encodes an 862 aa, 96 kDa polypeptide.Synonyms: DNA mismatch repair protein PMS2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2, PMSL2
基因ID 5395
UniProt P54278
途径 DNA Damage Repair, Production of Molecular Mediator of Immune Response
应用备注 ELISA: 1: 5,000 - 1: 20,000. Western blot: 1: 500 - 1: 2,000. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
浓度 1.38 mg/mL
缓冲液 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 a buffer and 0.09 % (w/v) Sodium Azide as preservative
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C/-20 °C
储存方法 Store the antibody at 2 °C to 8 °C up to one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Shelf life: one year from despatch.
有效期 12 months
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