This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This MLLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 523-552 amino acids from the C-terminal region of human MLLT1.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C,-20 °C
储存方法
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
抗原
MLLT1
(MLLT1, super elongation complex subunit (MLLT1))
MGC84026 antibody, MLLT1 antibody, ENL antibody, LTG19 antibody, YEATS1 antibody, AA407901 antibody, BAM11 antibody, MLLT1, super elongation complex subunit antibody, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 L homeolog antibody, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 antibody, Mllt1 antibody, MLLT1 antibody, mllt1.L antibody, mllt1 antibody
背景
Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in chimeric genes that encode an N-terminal portion of Hrx fused to various partner proteins. Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to Hrx in t(11,19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.