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- 抗原 See all SIGLEC10 抗体
- SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
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抗原表位
- AA 656-687, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SIGLEC10 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This SIGLEC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 656-687 amino acids from the C-terminal region of human SIGLEC10.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product SIGLEC10 Primary Antibody
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anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 571-697) antibody
SIGLEC10 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C5 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 571-697) antibodySIGLEC10 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 589-696) antibodySIGLEC10 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 589-696) antibodySIGLEC10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D11 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (Extracellular Domain) antibody (PE)SIGLEC10 适用: 人 FACS 宿主: 小鼠 Monoclonal 5G6 PE
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) antibodySIGLEC10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 321-420) antibodySIGLEC10 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (Extracellular Domain) antibodySIGLEC10 适用: 人 ELISA, IHC, IP 宿主: 小鼠 Monoclonal 5G6 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (Middle Region) antibodySIGLEC10 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- For WB starting dilution is: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
- 别名
- SIGLEC10 (SIGLEC10 产品)
- 别名
- PRO940 antibody, SIGLEC-10 antibody, SLG2 antibody, Siglecg antibody, SIGLEC10 antibody, slg2 antibody, pro940 antibody, siglec-10 antibody, sialic acid binding Ig like lectin 10 antibody, sialic acid binding Ig-like lectin 10 antibody, sialic acid-binding Ig-like lectin 10 antibody, SIGLEC10 antibody, Siglec10 antibody, LOC484343 antibody, LOC100066644 antibody, siglec10 antibody, LOC100513863 antibody, LOC100340374 antibody
- 背景
- SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC10 interacts with PTPN6/SHP-1 upon phosphorylation. The protein is expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform, found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells. SIGLEC10 contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. Phosphorylation of Tyr-667 is involved in binding to PTPN6. The SIGLEC10 gene belongs to the immunoglobulin superfamily.
- 分子量
- 77 kDa
- 基因ID
- 89790
- UniProt
- Q96LC7
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