Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
纯化方法
This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 amino acids from the Central region of human ADAMTS13.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C,-20 °C
储存方法
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
抗原
ADAMTS13
(ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13))
ADAMTS13 antibody, ADAM-TS13 antibody, ADAMTS-13 antibody, C9orf8 antibody, VWFCP antibody, vWF-CP antibody, Gm710 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 13 antibody, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 antibody, ADAM metallopeptidase with thrombospondin type 1 motif, 13 antibody, ADAMTS13 antibody, Adamts13 antibody, adamts13 antibody
背景
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.