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Vangl1 抗体 (AA 148-400)

Vangl1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5027627
发货至: 中国
  • 抗原 See all Vangl1 抗体
    Vangl1 (Vang-Like 1 (Vangl1))
    抗原表位
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 148-400
    适用
    • 27
    • 14
    • 7
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    宿主
    • 25
    • 3
    克隆类型
    • 27
    • 1
    多克隆
    标记
    • 17
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Vangl1 antibody is un-conjugated
    应用范围
    • 21
    • 8
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    纯化方法
    Protein A Chromatography
    免疫原
    A partial length recombinant Vang like-1 protein (amino acids 148-400) was used as the immunogen for this antibody.
    亚型
    IgG
    Top Product
    Discover our top product Vangl1 Primary Antibody
  • 应用备注
    WB: 2-4 μg/mL
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    PBS containing 0.05 % BSA, PH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • 抗原
    Vangl1 (Vang-Like 1 (Vangl1))
    别名
    Vang like-1 (Vangl1 产品)
    别名
    stb2 antibody, Kitenin antibody, Lpp2 antibody, Stb2 antibody, Stbm antibody, KITENIN antibody, LPP2 antibody, STB2 antibody, STBM2 antibody, VANGL planar cell polarity protein 1 antibody, vang-like 1 (van gogh, Drosophila) antibody, Vangl1 antibody, vangl1 antibody, VANGL1 antibody
    背景
    Vangl1 (VANGL planar cell polarity protein 1) is an integral membrane protein that belongs to the tetraspanin family having four transmembrane domains. Tetraspanins form large multimolecular complexes on the cell membrane and are involved in cellular signaling, membrane formation, and migration. Vangl1 is expressed at the plasma membrane of different tissues and play a critical role in establishing planar cell polarity (PCP) in epithelial cells and are required for convergent extension (CE) movements during embryogenesis. It is a highly conserved and have evolved from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the vangl1 gene cause NTDs (neural tube defects). Ser/Thr phosphorylation of Vangl1 serves as an effector mediating the ITF healing response of the intestinal mucosa. In colon carcinoma cell lines, Vangl1 interacts with KAI1 (CD82) tumor metastasis suppressor. Vangl1 overexpression increases motility and metastasis, whereas its inhibition decreases motility and metastasis of colon cancer confirming migratory phenotype for Vangl1 in colonic epithelial cells.
    分子量
    62 kDa
    基因ID
    81839
    UniProt
    Q8TAA9
    途径
    WNT signaling
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