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NOTUM 抗体 (AA 351-450) (Alexa Fluor 750)

NOTUM 适用: 人 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal Alexa Fluor 750
产品编号 ABIN5007785
发货至: 中国
  • 抗原 See all NOTUM 抗体
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    抗原表位
    • 14
    • 8
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    AA 351-450
    适用
    • 37
    • 3
    • 2
    宿主
    • 37
    克隆类型
    • 37
    多克隆
    标记
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOTUM antibody is conjugated to Alexa Fluor 750
    应用范围
    • 33
    • 21
    • 12
    • 12
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    预测反应
    Human,Mouse,Rat,Dog,Cow,Horse
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human NOTUM
    亚型
    IgG
    Top Product
    Discover our top product NOTUM Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    别名
    NOTUM (NOTUM 产品)
    别名
    5730593N15Rik antibody, RGD1307119 antibody, notum, palmitoleoyl-protein carboxylesterase antibody, notum pectinacetylesterase homolog (Drosophila) antibody, NOTUM, palmitoleoyl-protein carboxylesterase antibody, NOTUM antibody, Notum antibody
    背景

    Synonyms: NOTUM, notum pectinacetylesterase homolog Drosophila, Notum pectinacetylesterase homolog, NOTUM_HUMAN.

    Background: Notum is a 496 amino acid secreted protein that belongs to the pectinacetylesterase family and may deacetylate GlcNAc residues on cell surface glycans. The gene that encodes Notum consists of approximately 9,334 bases and maps to human chromosome 17q25.3. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5 % of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes.

    基因ID
    147111
    UniProt
    Q6P988
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