SLC22A17
适用: 人, 大鼠
WB, IF (cc), IF (p)
宿主: 兔
Polyclonal
FITC
应用备注
ELISA. Western blot: 1 μg/mL. Immunoflourescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
缓冲液
PBS containing 0.02 % sodium azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
抗原
SLC22A17
(Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))
1700094C23Rik antibody, 24p3R antibody, AU041908 antibody, AW555662 antibody, BOIT antibody, Boct antibody, mBOCT antibody, BOCT antibody, NGALR antibody, NGALR2 antibody, NGALR3 antibody, hBOIT antibody, rBOCT antibody, solute carrier family 22 member 17 antibody, solute carrier family 22 (organic cation transporter), member 17 antibody, solute carrier family 22, member 17 antibody, SLC22A17 antibody, Slc22a17 antibody
背景
The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.Synonyms: BOCT, BOIT, Brain-type organic cation transporter, Solute carrier family 22 member 17