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AATF 抗体

AATF 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499185
发货至: 中国
  • 抗原 See all AATF 抗体
    AATF (Apoptosis Antagonizing Transcription Factor (AATF))
    适用
    • 45
    • 14
    • 11
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    人, 小鼠
    宿主
    • 43
    • 3
    • 1
    克隆类型
    • 43
    • 4
    多克隆
    标记
    • 34
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
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    This AATF antibody is un-conjugated
    应用范围
    • 34
    • 21
    • 12
    • 8
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    AATF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human AATF.
    纯化方法
    Immunoaffinity purified IgG
    免疫原
    Human AATF Peptide
    亚型
    IgG
    Top Product
    Discover our top product AATF Primary Antibody
  • 应用备注
    ELISA. Western Blot: AATF antibody can be used for the detection of AATF at 0.5 - 1 μg/mL. Humansmall intestine cell lysate can be used as positive control. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    AATF (Apoptosis Antagonizing Transcription Factor (AATF))
    别名
    AATF (AATF 产品)
    别名
    AATF antibody, ded antibody, che1 antibody, che-1 antibody, cb109 antibody, sb:cb109 antibody, wu:fc13d05 antibody, zgc:162071 antibody, CHE-1 antibody, CHE1 antibody, DED antibody, 4933415H02Rik antibody, 5830465M17Rik antibody, Che-1 antibody, Trb antibody, Ded antibody, apoptosis antagonizing transcription factor antibody, Apoptosis antagonizing transcription factor antibody, apoptosis antagonizing transcription factor S homeolog antibody, AATF antibody, aatf antibody, BFR2 antibody, NAEGRDRAFT_56916 antibody, Aatf antibody, aatf.S antibody
    背景
    AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases (2). AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways (3). Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the b-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer's disease (AD) (4,5), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.Synonyms: Apoptosis-antagonizing transcription factor, CHE-1, CHE1, DED, HSPC277, Rb-binding protein Che-1
    基因ID
    26574
    NCBI登录号
    NP_036270
    UniProt
    Q9NY61
    途径
    Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome
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