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CELF1 抗体

CELF1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN498349
发货至: 中国
  • 抗原 See all CELF1 抗体
    CELF1 (CUGBP, Elav-Like Family Member 1 (CELF1))
    适用
    • 52
    • 23
    • 22
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 40
    • 12
    克隆类型
    • 40
    • 12
    多克隆
    标记
    • 28
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CELF1 antibody is un-conjugated
    应用范围
    • 36
    • 24
    • 20
    • 8
    • 8
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    This antibody detects endogenous levels of CUGBP1/2 protein. (region surrounding Lys95)
    交叉反应 (详细)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Also reacts to: CUGBP2
    纯化方法
    Affinity chromatography
    纯度
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product CELF1 Primary Antibody
  • 应用备注
    Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1,0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    CELF1 (CUGBP, Elav-Like Family Member 1 (CELF1))
    别名
    CUGBP1 (CELF1 产品)
    别名
    CUGBP1 antibody, BRUNOL2 antibody, CUG-BP antibody, CUGBP antibody, EDEN-BP antibody, NAB50 antibody, NAPOR antibody, hNab50 antibody, 1600010O03Rik antibody, AA407467 antibody, Brunol2 antibody, CUG-BP1 antibody, Cugbp1 antibody, D2Wsu101e antibody, HNAB50 antibody, Bruno-like antibody, brul antibody, cb920 antibody, cugbp1 antibody, brunol2 antibody, cug-bp antibody, cug-bp1 antibody, cugbp antibody, cugbp1-a antibody, eden-bp antibody, edenbp antibody, nab50 antibody, CUGBP Elav-like family member 1 antibody, CUGBP, Elav-like family member 1 antibody, cugbp, Elav-like family member 1 antibody, CUGBP Elav-like family member 1 L homeolog antibody, CELF1 antibody, Celf1 antibody, celf1 antibody, celf1.L antibody
    背景
    Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3'-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPbeta transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPbeta mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5' region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawal.Synonyms: 50 kDa nuclear polyadenylated RNA-binding protein, BRUNOL2, Bruno-like protein 2, CELF-1, CELF1, CUG triplet repeat RNA-binding protein 1, CUG-BP- and ETR-3-like factor 1, CUGBP, Deadenylation factor CUG-BP, Embryo deadenylation element-binding protein homolog, NAB50, RNA-binding protein BRUNOL-2
    分子量
    approx. 52 kDa
    基因ID
    10658
    NCBI登录号
    NP_001020767
    UniProt
    Q92879
    途径
    Ribonucleoprotein Complex Subunit Organization
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