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MARK1 抗体 (AA 671-700)

MARK1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3031688
发货至: 中国
  • 抗原 See all MARK1 抗体
    MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
    抗原表位
    • 10
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    AA 671-700
    适用
    • 62
    • 35
    • 12
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    人, 小鼠
    宿主
    • 62
    • 1
    克隆类型
    • 63
    多克隆
    标记
    • 26
    • 7
    • 6
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MARK1 antibody is un-conjugated
    应用范围
    • 49
    • 43
    • 33
    • 11
    • 8
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Purified
    免疫原
    A portion of amino acids 671-700 from the human protein was used as the immunogen for this MARK1 antibody.
    亚型
    Ig Fraction
    Top Product
    Discover our top product MARK1 Primary Antibody
  • 应用备注
    Titration of the MARK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Aliquot the MARK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原
    MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
    别名
    MARK1 (MARK1 产品)
    别名
    MGC80341 antibody, MARK1 antibody, AW491150 antibody, B930025N23Rik antibody, Emk3 antibody, Par-1c antibody, mKIAA1477 antibody, mPar-1c antibody, MARK antibody, Par1c antibody, MAP/microtubule affinity-regulating kinase 1 S homeolog antibody, microtubule affinity regulating kinase 1 antibody, MAP/microtubule affinity-regulating kinase 1 antibody, MAP/microtubule affinity regulating kinase 1 antibody, mark1.S antibody, MARK1 antibody, mark1 antibody, Mark1 antibody
    背景
    MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK
    UniProt
    Q9P0L2
    途径
    SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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