CYP1A1 抗体 (AA 183-320)
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- 抗原 See all CYP1A1 抗体
- CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))
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抗原表位
- AA 183-320
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CYP1A1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 纯化方法
- Antigen affinity
- 免疫原
- Amino acids 183-320 of human CYP1A1 were used as the immunogen for the CYP1A1 antibody.
- 亚型
- IgG
- Top Product
- Discover our top product CYP1A1 Primary Antibody
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anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 251-521) antibody
CYP1A1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 200-460) antibodyCYP1A1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (Internal Region) antibodyVerified CYP1A1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) antibodyCYP1A1 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 6G5 unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 183-320) antibodyCYP1A1 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) antibodyCYP1A1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (Middle Region) antibodyCYP1A1 适用: 人, 小鼠, 大鼠, 马, 豚鼠, 兔, 绵羊, Cow, 斑马鱼, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 377-405) antibodyCYP1A1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 252-280) antibodyCYP1A1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 1-250) antibodyCYP1A1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal dilution of the CYP1A1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Frozen): 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells
- 限制
- 仅限研究用
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- 缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- 储存条件
- -20 °C
- 储存方法
- After reconstitution, the CYP1A1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- 抗原
- CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))
- 别名
- CYP1A1 (CYP1A1 产品)
- 别名
- AHH antibody, AHRR antibody, CP11 antibody, CYP1 antibody, P1-450 antibody, P450-C antibody, P450DX antibody, Cyp1a2 antibody, P450-1 antibody, cyp1a1 antibody, CYP1A1 antibody, CYPIA1 antibody, Cyp45c antibody, Cypc45c antibody, P-450MC antibody, wu:fb63b04 antibody, zfCYP1A antibody, zgc:109747 antibody, ahh antibody, ahrr antibody, cp11 antibody, cyp1 antibody, cyp1a antibody, p1-450 antibody, p450-c antibody, p450dx antibody, cytochrome P450 family 1 subfamily A member 1 antibody, cytochrome P450 1A1 antibody, cytochrome P450, family 1, subfamily a, polypeptide 1 antibody, cytochrome P450, family 1, subfamily A, polypeptide 1 antibody, cytochrome P450 family 1 subfamily D polypeptide 1 antibody, cytochrome P4501A1 antibody, polycyclic hydrocarbon-inducible cytochrome P450c antibody, cytochrome P450, family 1, subfamily A antibody, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1 antibody, cytochrome P450 family 1 subfamily A member 1 L homeolog antibody, CYP1A1 antibody, CpipJ_CPIJ010542 antibody, Cyp1a1 antibody, cyp1d1 antibody, LOC100328613 antibody, cyp1a antibody, LOC102129994 antibody, cyp1a1.L antibody
- 背景
- CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons. CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It is involved in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAH), for example, benzo(a)pyrene (BP), by transforming it to an epoxide. In this reaction, the oxidation of benzo[a]pyrene is catalysed by CYP1A1 to form BP-7,8-epoxide, which can be further oxidized by epoxide hydrolase (EH) to form BP-7,8-dihydrodiol. Finally CYP1A1 catalyses this intermediate to form BP-7,8-dihydrodiol-9,10-epoxide, which is the ultimate carcinogen. However, an in vivo experiment with gene-deficient mice has found that the hydroxylation of benzo(a)pyrene by CYP1A1 can have an overall protective effect on the DNA, rather than contributing to potentially carcinogenic DNA modifications. This effect is likely due to the fact that CYP1A1 is highly active in the intestinal mucosa, and thus inhibits infiltration of ingested benzo(a)pyrene carcinogen into the systemic circulation.
- UniProt
- P04798
- 途径
- Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha
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