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CTDSP1 抗体 (C-Term, N-Term)

CTDSP1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN360805
发货至: 中国
  • 抗原 See all CTDSP1 抗体
    CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))
    抗原表位
    • 13
    • 13
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-250, C-Term, N-Term
    适用
    • 40
    • 11
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    宿主
    • 35
    • 3
    • 2
    克隆类型
    • 38
    • 2
    多克隆
    标记
    • 22
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CTDSP1 antibody is un-conjugated
    应用范围
    • 32
    • 20
    • 10
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts to CTDSP1-V250.
    纯化方法
    Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
    免疫原
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CTDSP1-V250 protein.
    亚型
    Ig Fraction
    Top Product
    Discover our top product CTDSP1 Primary Antibody
  • 应用备注
    ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS with 0.09 % (W/V) sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • 抗原
    CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))
    别名
    CTDSP1 (CTDSP1 产品)
    别名
    CTDSP1 antibody, NIF3 antibody, NLI-IF antibody, NLIIF antibody, SCP1 antibody, fj83f12 antibody, im:7141428 antibody, wu:fj83f12 antibody, zgc:113169 antibody, GIP antibody, Nif3 antibody, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 antibody, CTD small phosphatase 1 antibody, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody, CTDSP1 antibody, Ctdsp1 antibody, ctdsp1 antibody, HCAG_04820 antibody, CTRG_06220 antibody
    背景
    CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF, 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.Synonyms: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, NIF3, NLI-IF, NLI-interacting factor 3, NLIIF, SCP1, Small C-terminal domain phosphatase 1
    基因ID
    58190, 9606
    UniProt
    Q9GZU7
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