PLEKHG6
适用: 人
WB, IF (cc), IF (p)
宿主: 兔
Polyclonal
Alexa Fluor 488
应用备注
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
状态
Liquid
浓度
0.25 mg/mL
缓冲液
PBS with 0.09 % (W/V) sodium azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
抗原
PLEKHG6
(Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 (PLEKHG6))
MyoGEF antibody, BC026778 antibody, Gm155 antibody, pleckstrin homology and RhoGEF domain containing G6 antibody, pleckstrin homology domain containing, family G (with RhoGef domain) member 6 antibody, PLEKHG6 antibody, Plekhg6 antibody
背景
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It Also activates RHOG and does not activate RAC1, or to a much lower extent than RHOA and RHOG. Its part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, It is required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, it is required for normal macropinocytosis.Synonyms: Myosin-interacting guanine nucleotide exchange factor, PLEKHG6, Pleckstrin homology domain-containing family G member 6