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NEK2 抗体 (AA 396-426)

NEK2 适用: 人 WB 宿主: 兔 Polyclonal RB2959 unconjugated
产品编号 ABIN392650
发货至: 中国
  • 抗原 See all NEK2 抗体
    NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))
    抗原表位
    • 15
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 396-426
    适用
    • 92
    • 18
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 84
    • 7
    • 3
    克隆类型
    • 87
    • 7
    多克隆
    标记
    • 40
    • 8
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NEK2 antibody is un-conjugated
    应用范围
    • 79
    • 43
    • 15
    • 14
    • 13
    • 12
    • 10
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This NEK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-426 amino acids from the Central region of human NEK2.
    克隆位点
    RB2959
    亚型
    Ig Fraction
    Top Product
    Discover our top product NEK2 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Zhao, Han, Liu, Cui, Chen: "MicroRNA-128 promotes apoptosis in lung cancer by directly targeting NIMA-related kinase 2." in: Thoracic cancer, Vol. 8, Issue 4, pp. 304-311, (2018) (PubMed).

    Lin, Zhou, Jiang, Liu, Wang, Zheng, Zhou, Li, Cai: "NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma." in: Oncology reports, Vol. 36, Issue 2, pp. 853-62, (2017) (PubMed).

    Naro, Barbagallo, Chieffi, Bourgeois, Paronetto, Sette: "The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival." in: Nucleic acids research, Vol. 42, Issue 5, pp. 3218-27, (2014) (PubMed).

    van Ree, Jeganathan, Malureanu, van Deursen: "Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation." in: The Journal of cell biology, Vol. 188, Issue 1, pp. 83-100, (2010) (PubMed).

    Barbagallo, Paronetto, Franco, Chieffi, Dolci, Fry, Geremia, Sette: "Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas." in: The Journal of pathology, Vol. 217, Issue 3, pp. 431-41, (2009) (PubMed).

    Wu, Baxter, Wattam, Hayward, Fardilha, Knebel, Ford, da Cruz e Silva, Fry: "Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26431-40, (2007) (PubMed).

  • 抗原
    NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))
    别名
    NEK2 (NEK2 产品)
    别名
    AA617254 antibody, C77054 antibody, HsPK21 antibody, NEK2A antibody, NLK1 antibody, ATNEK2 antibody, NIMA-RELATED KINASE2 antibody, NIMA-related kinase 2 antibody, T9J14.24 antibody, T9J14_24 antibody, NIMA related kinase 2 antibody, NIMA (never in mitosis gene a)-related expressed kinase 2 antibody, NIMA-related kinase 2 antibody, NEK2 antibody, Nek2 antibody
    背景
    Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
    分子量
    51763
    基因ID
    4751
    NCBI登录号
    NP_001191111, NP_001191112, NP_002488
    UniProt
    P51955
    途径
    M Phase
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