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- 抗原 See all PICK1 抗体
- PICK1 (Protein Interacting With Protein Kinase C, alpha 1 (PICK1))
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抗原表位
- AA 1-30, N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PICK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- Pr, Rat
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This PICK1 (PRKCABP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PICK1 (PRKCABP).
- 克隆位点
- RB05473-05474
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PICK1 Primary Antibody
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anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) antibody
PICK1 适用: 人 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) (AA 1-200) antibodyPICK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) (AA 266-375) antibodyPICK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G5 unconjugated
anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) (Internal Region) antibodyVerified PICK1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) (AA 24-229) antibodyPICK1 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) (C-Term) antibodyPICK1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) (N-Term) antibodyPICK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) (AA 260-360) antibodyPICK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) (AA 305-318), (alpha-helix Domain), (Intracellular) antibodyPICK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Interacting With Protein Kinase C, alpha 1 (PICK1) (AA 266-375) antibodyPICK1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- PICK1 (Protein Interacting With Protein Kinase C, alpha 1 (PICK1))
- 别名
- PICK1 (PRKCABP) (PICK1 产品)
- 别名
- PICK antibody, PRKCABP antibody, Prkcabp antibody, prkcabp antibody, MGC131295 antibody, PICK1 antibody, DKFZp470L2127 antibody, protein interacting with PRKCA 1 antibody, protein interacting with C kinase 1 antibody, protein interacting with PRKCA 1 L homeolog antibody, PICK1 antibody, Pick1 antibody, pick1 antibody, pick1.L antibody
- 背景
- PDZ domain, but not the AH domain, of PICK1 interacts with the C termini of the GTP-bound forms of ADP-ribosylation factor-1 (ARF1) and ARF3. The interactions with ARF5 and ARF6 are weak, suggesting that the PICK1 interaction is specific for class I ARFs and that it may regulate Golgi-to-endoplasmic reticulum vesicle transport. The PDZ domain of rat Pick1 interacts with the last 10 amino acids of the short C-terminal alternative splice variants of AMPA receptor subunits. It has thus been proposed that E-S-V/I-K-I, a sequence found in these 10 amino acids, is a novel PDZ-binding motif. PRKCA phosphorylates Pick1 efficiently but binds Pick1 in both the phosphorylated and unphosphorylated states. Consistent with a neuronal role for PICK1, the mouse homolog interacts with mouse AMPA glutamate receptors and colocalizes at excitatory synapses in the brain. Metabotropic glutamate receptor-7 (mGluR7) localizes specifically to presynaptic active zones. The extreme C-terminal 3 amino acids of mGluR7 have been shown to interact with the PDZ domain of PICK1. Immunofluorescence microscopy demonstrated that both proteins are localized at excitatory synapses in hippocampal neurons, with clustering of mGluR7 at synapses requires PICK1 C-terminal PDZ-binding residues. Mutant mGluR7 lacking the PDZ-binding residues localized diffusely along axons rather than at the synapse, suggesting a role for Pick1 as a scaffolding molecule at presynaptic sites.
- 分子量
- 46600
- 基因ID
- 9463
- NCBI登录号
- NP_001034672, NP_001034673, NP_036539
- UniProt
- Q9NRD5
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