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MTOR 抗体 (AA 2459-2488)

mTOR 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB13347 unconjugated
产品编号 ABIN390217
发货至: 中国
  • 抗原 See all MTOR (mTOR) 抗体
    MTOR (mTOR) (Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
    抗原表位
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    AA 2459-2488
    适用
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    宿主
    • 193
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    克隆类型
    • 173
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    多克隆
    标记
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    This MTOR antibody is un-conjugated
    应用范围
    • 147
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    M, Rat
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This mTOR (FRAP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2459-2488 amino acids from human mTOR (FRAP1).
    克隆位点
    RB13347
    亚型
    Ig Fraction
    Top Product
    Discover our top product mTOR Primary Antibody
  • 应用备注
    IF: 1:10~50. WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Yang, Cheng, Zhou, Zhu, Hu, Yang: "Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K/mTOR in Human Osteosarcoma." in: International journal of molecular sciences, Vol. 16, Issue 12, pp. 28635-46, (2016) (PubMed).

    Liu, Wu, Huang: "Orientin protects myocardial cells against hypoxia-reoxygenation injury through induction of autophagy." in: European journal of pharmacology, Vol. 776, pp. 90-8, (2016) (PubMed).

    Cao, Dong, Meng, Liu, Liao, Liu: "MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3." in: Tumour biology, Vol. 36, Issue 6, pp. 4453-9, (2015) (PubMed).

  • 抗原
    MTOR (mTOR) (Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
    别名
    mTOR (FRAP1) (mTOR 产品)
    别名
    FRAP1 antibody, FRAP antibody, FRAP2 antibody, RAFT1 antibody, RAPT1 antibody, 2610315D21Rik antibody, AI327068 antibody, Frap1 antibody, flat antibody, frap1 antibody, tor antibody, wu:fc22h08 antibody, mechanistic target of rapamycin kinase antibody, mechanistic target of rapamycin antibody, mechanistic target of rapamycin (serine/threonine kinase) antibody, MTOR antibody, Mtor antibody, mtor antibody
    背景
    FRAP1 belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. FRAP1 is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
    分子量
    288892
    基因ID
    2475
    NCBI登录号
    NP_004949
    UniProt
    P42345
    途径
    PI3K-Akt Signaling, RTK signaling, AMPK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, BCR Signaling, Warburg Effect
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