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ACO2 抗体 (AA 438-467)

Name: ACO2 抗体 (AA 438-467)
SKU: ABIN388648
Availability: OutOfStock

ACO2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB9338 unconjugated

Anti-Aconitase Antibody at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 μg per lane.

Formalin-fixed and paraffin-embedded human Heart tissue reacted with ACO2 Antibody (Center) (ABIN388648 and ABIN2838363) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

IHC (p)

Perfused isolated rat heart whole tissue lysate was lysed with either A) 50 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, 1 % NP-40, 0.

ACO2 (ABIN388648 and ABIN2838363) western blot analysis in 293 cell line lysates (35 μg/lane).

4 images

(5 references)

产品编号 ABIN388648

发货至: 中国

Datasheet as PDF

抗原 See all ACO2 抗体

ACO2 (Aconitase 2, Mitochondrial (ACO2))
抗原表位
7

6

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 438-467
适用
58

35

34

4

3

2

2

2

2

2

1

1

1

1

1
人, 大鼠
宿主
52

4

2
兔
Compatible Secondaries
克隆类型
45

13
多克隆
标记
33

6

3

2

2

2

2

2

2

2

1

1
This ACO2 antibody is un-conjugated
应用范围
38

25

19

7

5

5

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

预测反应

B, M, Pig

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This ACO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-467 amino acids from the Central region of human ACO2.

克隆位点

RB9338

亚型

Ig Fraction

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anti-Aconitase 2, Mitochondrial (ACO2) (N-Term) antibody
ACO2 适用: 人, 大鼠, 小鼠, Cow, 犬, Saccharomyces cerevisiae, 兔, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Ruiz, Bégou, Launay, Ranea-Robles, Bianchi, López-Erauskin, Morató, Guilera, Petit, Vaurs-Barriere, Guéret-Gonthier, Bonnet-Dupeyron, Fourcade, Auwerx, Boespflug-Tanguy, Pujol: "Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease." in: Brain pathology (Zurich, Switzerland), (2017) (PubMed).

Navarro, Botella, Metzendorf, Lind, Schneuwly: "Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich?s ataxia." in: Free radical biology & medicine, Vol. 85, pp. 71-82, (2015) (PubMed).

Fernandes, Uytterhoeven, Kuenen, Wang, Slabbaert, Swerts, Kasprowicz, Aerts, Verstreken: "Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration." in: The Journal of cell biology, Vol. 207, Issue 4, pp. 453-62, (2014) (PubMed).

Maity, Bindu, Dey, Goyal, Alam, Pal, Mitra, Bandyopadhyay et al.: "Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel ..." in: The Journal of biological chemistry, Vol. 284, Issue 5, pp. 3058-68, (2009) (PubMed).

OConnell, Gannon, Doran, Ohlendieck: "Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle." in: International journal of molecular medicine, Vol. 20, Issue 2, pp. 145-53, (2007) (PubMed).
抗原

ACO2 (Aconitase 2, Mitochondrial (ACO2))

别名

ACO2 (ACO2 产品)

别名

DDBDRAFT_0206187 antibody, DDBDRAFT_0230168 antibody, DDB_0206187 antibody, DDB_0230168 antibody, aconitase 2 antibody, F10M23.310 antibody, F10M23_310 antibody, ACONM antibody, ICRD antibody, Aco-2 antibody, Aco3 antibody, D10Wsu183e antibody, cb1017 antibody, wu:fa10e03 antibody, wu:fb69g04 antibody, wu:fc20c11 antibody, aconitase 2 antibody, aconitase 2 S homeolog antibody, aconitate hydratase, mitochondrial antibody, aconitase, mitochondrial antibody, mitochondrial aconitate hydratase antibody, aconitase 2, mitochondrial antibody, Probable aconitate hydratase, mitochondrial antibody, ACO2 antibody, aco2.S antibody, Bm1_07420 antibody, aco2 antibody, ach1 antibody, Aco2 antibody, aco-2 antibody

背景

ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

分子量

85425

基因ID

50

NCBI登录号

NP_001089

UniProt

Q99798