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KCNC1 抗体 (pSer503)

KCNC1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN361488
发货至: 中国
  • 抗原 See all KCNC1 抗体
    KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))
    抗原表位
    • 17
    • 15
    • 9
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer503
    适用
    • 62
    • 17
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 65
    • 1
    克隆类型
    • 65
    • 1
    多克隆
    标记
    • 19
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This KCNC1 antibody is un-conjugated
    应用范围
    • 54
    • 26
    • 26
    • 25
    • 14
    • 9
    • 8
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    特异性
    Specific for the ~100k Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.
    交叉反应
    小鼠, 大鼠
    纯化方法
    Antigen Affinity Purified from Pooled Serum
    免疫原
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH
  • 应用备注
    Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    储存条件
    -20 °C
  • Sagi, Medrihan, George, Barney, McCabe, Greengard: "Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action." in: Molecular psychiatry, Vol. 25, Issue 6, pp. 1191-1201, (2020) (PubMed).

  • 抗原
    KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))
    别名
    KCNC1 (KCNC1 产品)
    别名
    kv3.1 antibody, C230009H10Rik antibody, KShIIIB antibody, KV4 antibody, Kcr2-1 antibody, Kv3.1 antibody, NGK2 antibody, Shaw antibody, Kv4 antibody, NGK2-KV4 antibody, KV3.1 antibody, KCNC2 antibody, zgc:194940 antibody, zgc:194950 antibody, potassium voltage-gated channel subfamily C member 1 antibody, potassium voltage-gated channel, Shaw-related subfamily, member 1 antibody, potassium voltage gated channel, Shaw-related subfamily, member 1 antibody, potassium voltage-gated channel, Shaw-related subfamily, member 1a antibody, KCNC1 antibody, kcnc1 antibody, Kcnc1 antibody, kcnc1a antibody
    背景
    Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995, Pongs, 1999, Blaine and Ribera, 1998, Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
    分子量
    '100 kDa
    基因ID
    25327
    UniProt
    P25122
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