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GABRB2 抗体 (Cytoplasmic Loop)

GABRB2 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN361447
发货至: 中国
  • 抗原 See all GABRB2 抗体
    GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))
    抗原表位
    • 15
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    Cytoplasmic Loop
    适用
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    大鼠
    宿主
    • 77
    • 1
    克隆类型
    • 77
    • 1
    多克隆
    标记
    • 31
    • 6
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    This GABRB2 antibody is un-conjugated
    应用范围
    • 68
    • 29
    • 26
    • 26
    • 9
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    • 3
    • 3
    • 1
    Western Blotting (WB)
    特异性
    Specific for the ~55k ß2-subunit of the GABAA receptor in Western blots.
    交叉反应
    小鼠, 大鼠
    预测反应
    canine, human, non-human primate
    纯化方法
    Antigen Affinity Purified
    免疫原
    Fusion protein from the cytoplasmic loop of the beta 2 subunit
  • 应用备注
    Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    储存条件
    -20 °C
  • Antflick, Hampson: "Modulation of glutamate release from parallel fibers by mGlu4 and pre-synaptic GABA(A) receptors." in: Journal of neurochemistry, Vol. 120, Issue 4, pp. 552-63, (2012) (PubMed).

  • 抗原
    GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))
    别名
    GABRB2 (GABRB2 产品)
    别名
    GABRB2 antibody, GARB2 antibody, fj59e04 antibody, gabaabeta2 antibody, wu:fj59e04 antibody, zgc:136311 antibody, GABARB antibody, AI834970 antibody, C030002O17Rik antibody, C030021G16Rik antibody, Gabrab2 antibody, Gabrb-2 antibody, gamma-aminobutyric acid type A receptor beta2 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, beta 2 antibody, gamma-aminobutyric acid type A receptor beta 2 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 antibody, GABRB2 antibody, gabrb2 antibody, Gabrb2 antibody
    背景
    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003). Anti-GABAA-Receptor, (2-Subunit Western blot of 7 (g of rat cerebellum (Cb) showing specific immunolabeling of the ~55k ß2-subunit of the GABAA-R.
    分子量
    '55 kDa
    基因ID
    25451
    UniProt
    P63138
    途径
    Sensory Perception of Sound, Synaptic Membrane
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