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BRF1 抗体

BRF1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN317615
发货至: 中国
  • 抗原 See all BRF1 抗体
    BRF1 (BRF1, RNA polymerase III transcription initiation factor subunit (BRF1))
    适用
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    人, 小鼠
    宿主
    • 57
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    克隆类型
    • 59
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    多克隆
    标记
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    This BRF1 antibody is un-conjugated
    应用范围
    • 51
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    • 5
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    This antibody detects endogenous levels of TFIIIB90-1 protein.(region surrounding Glu257)
    纯化方法
    Affinity Chromatography using epitope-specific immunogen
    Top Product
    Discover our top product BRF1 Primary Antibody
  • 应用备注
    Western Blot: 1/500-1/1000. ELISA: 1/1000-1/5000. Immunohistochemistry: 1/50-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    BRF1 (BRF1, RNA polymerase III transcription initiation factor subunit (BRF1))
    别名
    BRF1 / TFIIIB90 (BRF1 产品)
    别名
    BRF antibody, BRF-1 antibody, GTF3B antibody, TAF3B2 antibody, TAF3C antibody, TAFIII90 antibody, TF3B90 antibody, TFIIIB90 antibody, hBRF antibody, DDBDRAFT_0189159 antibody, DDBDRAFT_0216283 antibody, DDB_0189159 antibody, DDB_0216283 antibody, 2510002F24Rik antibody, mTFIIIB90 antibody, BRF1 antibody, ZFP36L1 antibody, CG31256 antibody, CG4155 antibody, CG5419 antibody, Dmel\\CG31256 antibody, TFIIIB antibody, brf antibody, brf1 antibody, wu:fi47f03 antibody, zgc:55543 antibody, fi40c10 antibody, wu:fi40c10 antibody, zgc:63497 antibody, BRF1, RNA polymerase III transcription initiation factor subunit antibody, transcription initiation factor IIB antibody, general transcription factor IIB antibody, cilia and flagella associated protein 20 antibody, transcription factor IIb, putative antibody, transcription factor IIB antibody, transcription factor IIb antibody, Transcription factor iib, putative antibody, BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit antibody, CG31256 gene product from transcript CG31256-RA antibody, BRF1, RNA polymerase III transcription initiation factor a antibody, BRF1, RNA polymerase III transcription initiation factor b antibody, BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit L homeolog antibody, BRF1 antibody, gtf2b antibody, GTF2B antibody, cfap20 antibody, PFE0415w antibody, Tb09.160.4220 antibody, PVX_097980 antibody, CpipJ_CPIJ011738 antibody, CpipJ_CPIJ014799 antibody, CpipJ_CPIJ018710 antibody, PKH_102450 antibody, Brf1 antibody, Brf antibody, brf1a antibody, brf1b antibody, brf1.L antibody
    背景
    RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in alignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (TFIIIB90, BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.Synonyms: B-related factor 1, BRF, GTF3B, RNA polymerase III subunit 2, TAF3B2, TAF3C, TATA box-binding protein-associated factor, Transcription factor IIIB 90 kDa subunit
    分子量
    approx. 74 kDa
    基因ID
    2972
    NCBI登录号
    NP_001510
    UniProt
    Q92994
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