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SNAP25 抗体 (C-Term)

SNAP25 适用: 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3044363
发货至: 中国
  • 抗原 See all SNAP25 抗体
    SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))
    抗原表位
    • 16
    • 15
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    AA 186-200, C-Term
    适用
    • 93
    • 63
    • 61
    • 9
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    • 5
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    • 1
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    大鼠
    宿主
    • 95
    • 20
    • 4
    • 4
    • 1
    克隆类型
    • 94
    • 27
    • 1
    多克隆
    标记
    • 70
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    This SNAP25 antibody is un-conjugated
    应用范围
    • 89
    • 47
    • 27
    • 18
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    • 9
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    原理
    Rabbit IgG polyclonal antibody for Synaptosomal-associated protein 25(SNAP25) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    序列
    DSNKTRIDEA NQRAT
    交叉反应 (详细)
    Predicted Cross Reactivity: human, mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    产品特性
    Rabbit IgG polyclonal antibody for Synaptosomal-associated protein 25(SNAP25) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: synaptosomal-associated protein, 25 kDa
    Protein Name: Synaptosomal-associated protein 25(SNAP-25)
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the C-terminus of human SNAP25(186-200aa DSNKTRIDEANQRAT), identical to the related rat and mouse sequences.
    亚型
    IgG
    Top Product
    Discover our top product SNAP25 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    有效期
    12 months
  • Zhong, Xiang, Hu, Wang, Zeng, Wang, Xia, Wang, Zhang: "Synaptosomal-associated protein 25 may be an intervention target for improving sensory and locomotor functions after spinal cord contusion." in: Neural regeneration research, Vol. 12, Issue 6, pp. 969-976, (2017) (PubMed).

  • 抗原
    SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))
    别名
    SNAP25 (SNAP25 产品)
    别名
    RIC-4 antibody, RIC4 antibody, SEC9 antibody, SNAP antibody, SNAP-25 antibody, bA416N4.2 antibody, dJ1068F16.2 antibody, SNAP-25B antibody, SNAP-25a antibody, ric-4 antibody, ric4 antibody, sec9 antibody, snap-25 antibody, Bdr antibody, sp antibody, fj55h11 antibody, snap25 antibody, wu:fj55h11 antibody, Snap antibody, snap25.2 antibody, wu:fj33h05 antibody, synaptosome associated protein 25 antibody, synaptosome associated protein 25kDa S homeolog antibody, synaptosomal-associated protein, 25kDa antibody, synaptosomal-associated protein 25 antibody, synaptosome associated protein 25kDa antibody, synaptosome associated protein 25kDa L homeolog antibody, zgc:101731 antibody, synaptosomal-associated protein, 25b antibody, SNAP25 antibody, Snap25 antibody, snap25.S antibody, snap25 antibody, BACOIKO003_07 antibody, Tsp_10811 antibody, snap25.L antibody, zgc:101731 antibody, snap25b antibody
    背景
    Synaptosome-associated protein of 25,000 daltons also known as SNAP-25 is a protein which in humans encodes a 25-kD protein of 206 amino acids. It was first investigated as a neuron-specific gene preferentially expressed in mouse hippocampus. The tSNARE(the target-membrane soluble NSF-attachment protein receptor, where NSF is N-ethylmaleimide-sensitive fusion protein) synaptosomal-associated protein of 25 kDa(SNAP-25) is expressed in pancreatic B-cells and its cleavage by botulinum neurotoxin E(BoNT/E) abolishes stimulated secretion of insulin. In the nervous system, two SNAP-25 isoforms(a and b) have been described, which are produced by alternative splicing. Nagy et al.(2004) identified mammalian Snap25a and Snap25b as targets of protein kinase A, a key regulator of neurosecretion that primes slowly releasable pools and readily releasable pools of secretory vesicles. SNAP-25 inhibits P/Q- and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP-25 decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses.

    Synonyms: bA416N4.2 antibody|Bdr antibody|dJ1068F16.2 antibody|FLJ23079 antibody|HGNC:11132 antibody|MGC105414 antibody|MGC139754 antibody|Resistance to inhibitors of cholinesterase 4 homolog antibody|RIC 4 antibody|RIC4 antibody|SEC 9 antibody|SEC9 antibody|SNAP 25 antibody|SNAP antibody|SNAP-25 antibody|SNAP-25B antibody|SNAP25 antibody|SNP 25 antibody|SNP25 antibody|SNP25_HUMAN antibody|sp antibody|SUP antibody|Super protein antibody|Synaptosomal associated 25 kDa protein antibody|Synaptosomal associated protein antibody|Synaptosomal Associated Protein 25 antibody|Synaptosomal associated protein 25 kDa antibody|Synaptosomal-associated 25 kDa protein antibody|Synaptosomal-associated protein 25 antibody|Synaptosomal-associated protein, 25-KD antibody
    UniProt
    P60880
    途径
    Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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