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- 抗原 See all PCSK1 抗体
- PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
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抗原表位
- AA 726-740, C-Term
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适用
- 大鼠, 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PCSK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- Rabbit IgG polyclonal antibody for Neuroendocrine convertase 1(PCSK1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
- 序列
- DVFYNTKPYK HRDDR
- 交叉反应 （详细）
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Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities. - 产品特性
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Rabbit IgG polyclonal antibody for Neuroendocrine convertase 1(PCSK1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: proprotein convertase subtilisin/kexin type 1
Protein Name: Neuroendocrine convertase 1 - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human PC1/3(726-740aa DVFYNTKPYKHRDDR), identical to the related mouse and rat sequences.
- 亚型
- IgG
- Top Product
- Discover our top product PCSK1 Primary Antibody
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anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 500-738) antibody
PCSK1 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 244-530) antibodyPCSK1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 652-753) antibodyPCSK1 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 652-754) antibodyPCSK1 适用: 大鼠, 人, 小鼠 WB, IHC (p), IF, EIA 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 682-715) antibodyPCSK1 适用: 大鼠, 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB55298 unconjugated
anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 683-732) antibodyPCSK1 适用: 人, 豚鼠, 马, Cow, 犬, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 652-753) antibodyPCSK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G12 unconjugated
anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 175-207) antibodyPCSK1 适用: 大鼠 WB 宿主: 兔 Polyclonal RB55297 unconjugated
anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (Middle Region) antibodyPCSK1 适用: 大鼠, 人, 小鼠, 豚鼠, 马, 兔, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, The detection limit for PCSK1 is approximately 1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- 储存液
- Thimerosal (Merthiolate), Sodium azide
- 注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - 有效期
- 12 months
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- 抗原
- PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
- 别名
- PCSK1 (PCSK1 产品)
- 别名
- BMIQ12 antibody, NEC1 antibody, PC1 antibody, PC3 antibody, SPC3 antibody, Nec-1 antibody, Nec1 antibody, Phpp-1 antibody, BDP antibody, PC1/3 antibody, proprotein convertase subtilisin/kexin type 1 antibody, prohormone convertase 1 antibody, PCSK1 antibody, Pcsk1 antibody, pcsk1 antibody, PC1B antibody
- 背景
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PCSK1(Proprotein Convertase, Subtilisin/Kexin-Type, 1), also known as PC1 or NEC1, is an enzyme that in humans is encoded by the PCSK1 gene. Proprotein convertase-1 is a neuroendocrine convertase that belongs to a family of subtilisin-like serine endoproteases that process large precursor proteins into mature bioactive products. By in situ hybridization, Seidah et al.(1991) mapped the NEC1 gene to human chromosome 5q15-q21 and mouse chromosome 13. Ohagi et al.(1996) noted that PC1 initiates the sequential processing of proinsulin to insulin by cleaving the proinsulin molecule on the C-terminal side of the dibasic peptide, arg31-arg32, joining the B-chain and C-peptide. By observing the phenotypic features in patients with PC1 mutations, Jackson et al.(2003) concluded that human intestinal absorptive function is dependent on PC1 activity.
Synonyms: BDP antibody|EC antibody|NEC 1 antibody|NEC1 antibody|NEC1_HUMAN antibody|Neuroendocrine convertase 1 antibody|PC1 antibody|PC3 antibody|PCSK1 antibody|Prohormone convertase 1 antibody|Prohormone convertase 1/3 antibody|Prohormone convertase 3 antibody|Proprotein convertase 1 antibody|SPC3 antibody - UniProt
- P29120
- 途径
- Peptide Hormone Metabolism
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