CYP1A1 抗体 (AA 183-320)
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- 抗原 See all CYP1A1 抗体
- CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))
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抗原表位
- AA 183-320
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CYP1A1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 原理
- Rabbit IgG polyclonal antibody for Cytochrome P450 1A1(CYP1A1) detection. Tested with WB, IHC-P, IHC-F in Human,Mouse,Rat.
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
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Rabbit IgG polyclonal antibody for Cytochrome P450 1A1(CYP1A1) detection. Tested with WB, IHC-P, IHC-F in Human,Mouse,Rat.
Gene Name: cytochrome P450, family 1, subfamily A, polypeptide 1
Protein Name: Cytochrome P450 1A1 - 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human CYP1A1 recombinant protein (Position: H183-D320). Human CYP1A1 shares 81.2% amino acid (aa) sequence identity with both mouse and rat CYP1A1.
- 亚型
- IgG
- Top Product
- Discover our top product CYP1A1 Primary Antibody
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anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 251-521) antibody
CYP1A1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 200-460) antibodyCYP1A1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (Internal Region) antibodyVerified CYP1A1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) antibodyCYP1A1 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 6G5 unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 183-320) antibodyCYP1A1 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) antibodyCYP1A1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (Middle Region) antibodyCYP1A1 适用: 人, 小鼠, 大鼠, 马, 豚鼠, 兔, 绵羊, Cow, 斑马鱼, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 377-405) antibodyCYP1A1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 252-280) antibodyCYP1A1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1) (AA 1-250) antibodyCYP1A1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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- 抗原
- CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))
- 别名
- CYP1A1 (CYP1A1 产品)
- 别名
- AHH antibody, AHRR antibody, CP11 antibody, CYP1 antibody, P1-450 antibody, P450-C antibody, P450DX antibody, Cyp1a2 antibody, P450-1 antibody, cyp1a1 antibody, CYP1A1 antibody, CYPIA1 antibody, Cyp45c antibody, Cypc45c antibody, P-450MC antibody, wu:fb63b04 antibody, zfCYP1A antibody, zgc:109747 antibody, ahh antibody, ahrr antibody, cp11 antibody, cyp1 antibody, cyp1a antibody, p1-450 antibody, p450-c antibody, p450dx antibody, cytochrome P450 family 1 subfamily A member 1 antibody, cytochrome P450 1A1 antibody, cytochrome P450, family 1, subfamily a, polypeptide 1 antibody, cytochrome P450, family 1, subfamily A, polypeptide 1 antibody, cytochrome P450 family 1 subfamily D polypeptide 1 antibody, cytochrome P4501A1 antibody, polycyclic hydrocarbon-inducible cytochrome P450c antibody, cytochrome P450, family 1, subfamily A antibody, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1 antibody, cytochrome P450 family 1 subfamily A member 1 L homeolog antibody, CYP1A1 antibody, CpipJ_CPIJ010542 antibody, Cyp1a1 antibody, cyp1d1 antibody, LOC100328613 antibody, cyp1a antibody, LOC102129994 antibody, cyp1a1.L antibody
- 背景
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CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons. CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It is involved in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAH), for example, benzo(a)pyrene (BP), by transforming it to an epoxide. In this reaction, the oxidation of benzo[a]pyrene is catalysed by CYP1A1 to form BP-7,8-epoxide, which can be further oxidized by epoxide hydrolase (EH) to form BP-7,8-dihydrodiol. Finally CYP1A1 catalyses this intermediate to form BP-7,8-dihydrodiol-9,10-epoxide, which is the ultimate carcinogen. However, an in vivo experiment with gene-deficient mice has found that the hydroxylation of benzo(a)pyrene by CYP1A1 can have an overall protective effect on the DNA, rather than contributing to potentially carcinogenic DNA modifications. This effect is likely due to the fact that CYP1A1 is highly active in the intestinal mucosa, and thus inhibits infiltration of ingested benzo(a)pyrene carcinogen into the systemic circulation.
Synonyms: AHH antibody|AHRR antibody|Aryl hydrocarbon hydroxylase antibody|CP 11 antibody|CP11 antibody|CP1A1_HUMAN antibody|CYP 1 antibody|CYP1 antibody|CYP1A1 antibody|CYPIA1 antibody| Cytochrome P1 450 dioxin inducible antibody|Cytochrome P1-450 antibody|Cytochrome P1-450 dioxin-inducible antibody|Cytochrome P450 1A1 antibody|Cytochrome P450 family 1 subfamily A polypeptide 1 antibody|Cytochrome P450 form 6 antibody|Cytochrome P450 subfamily I (aromatic compound inducible) polypeptide 1 antibody|Cytochrome P450 subfamily I aromatic compound inducible polypeptide 1 antibody|Cytochrome P450-C antibody|Cytochrome P450-P1 antibody|Flavoprotein-linked monooxygenase antibody|Microsomal monooxygenase antibody|P1 450 antibody|P450 C antibody|P450 form 6 antibody|P450 P1 antibody|P450DX antibody| Xenobiotic monooxygenase antibody - 基因ID
- 1543
- UniProt
- P04798
- 途径
- Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha
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