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E-cadherin 抗体 (AA 286-703)

Name: E-cadherin 抗体 (AA 286-703)
SKU: ABIN3043808
Availability: OutOfStock

CDH1 适用: 人 WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

IHC (p)

3 images

(30 references)

产品编号 ABIN3043808

发货至: 中国

Datasheet as PDF

抗原 See all E-cadherin (CDH1) 抗体

E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
抗原表位
17

17

16

11

10

10

8

8

7

7

5

4

4

4

4

4

4

4

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 286-703
适用
225

96

83

18

17

12

9

9

9

6

4

4

4

4

1

1

1

1

1

1
人
宿主
192

72

7

3
兔
Compatible Secondaries
克隆类型
178

95

1
多克隆
标记
134

34

28

8

7

6

6

6

6

6

6

6

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This E-cadherin antibody is un-conjugated
应用范围
192

88

82

63

53

50

38

35

29

27

17

15

5

5

4

4

3

3

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

原理

Rabbit IgG polyclonal antibody for Cadherin-1(CDH1) detection. Tested with WB, IHC-P, IHC-F, ELISA in Human.

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Cadherin-1(CDH1) detection. Tested with WB, IHC-P, IHC-F, ELISA in Human.
Gene Name: cadherin 1, type 1, E-cadherin (epithelial)
Protein Name: Cadherin-1

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human E Cadherin recombinant protein (Position: A286-A703). Human E Cadherin shares 79.7% and 80.9% amino acid (aa) sequence identity with mouse and rat E Cadherin, respectively.

亚型

IgG

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CDH1 适用: 人, 小鼠, 大鼠, 猴, 犬 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated

anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody
CDH1 适用: 人, 小鼠, 大鼠, Pig, 猴, 犬, 小鸡, 兔, Cow, 马, 豚鼠, Avian, Cat, 驴, 山羊, Hamster, 绵羊 WB, IHC 宿主: 山羊 Polyclonal unconjugated

anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody
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anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 375-631) antibody
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anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 155-707) antibody
CDH1 适用: 人 WB, FACS, ELISA, IF 宿主: 小鼠 Monoclonal 9H2D3 unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Liu, Li, Li, Teng, Wang, Zhang, Xiao: "TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21." in: Scientific reports, Vol. 6, pp. 32231, (2018) (PubMed).

Zhang, Yao, Luan, Zhao, Jing, Zhang, Hou, Zou: "APC/CCDC20 and APC/C play pivotal roles in the process of embryonic development in Artemia sinica." in: Scientific reports, Vol. 6, pp. 39047, (2018) (PubMed).

Zhang, Bu, Sun, Xu, Yao, He, Lai: "Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 270, (2018) (PubMed).

Huang, Zheng, Pan, Wu, Su, Li, Wu, Sun: "Oral exposure of low-dose bisphenol A promotes proliferation of dorsolateral prostate and induces epithelial-mesenchymal transition in aged rats." in: Scientific reports, Vol. 8, Issue 1, pp. 490, (2018) (PubMed).

Wan, Tian, Qi, Liu, Xu: "ANXA1 affects cell proliferation, invasion and epithelial-mesenchymal transition of oral squamous cell carcinoma." in: Experimental and therapeutic medicine, Vol. 14, Issue 5, pp. 5214-5218, (2017) (PubMed).

Wang, An, Yu, Zhang, Tang, Zhang, Li: "MiR-29b/TET1/ZEB2 signaling axis regulates metastatic properties and epithelial-mesenchymal transition in breast cancer cells." in: Oncotarget, Vol. 8, Issue 60, pp. 102119-102133, (2017) (PubMed).

Lei, Lai, Bai, Qiu, Yang, Liao, Chuong, Yang, Lian, Zhong: "Prolonged overexpression of Wnt10b induces epidermal keratinocyte transformation through activating EGF pathway." in: Histochemistry and cell biology, Vol. 144, Issue 3, pp. 209-21, (2016) (PubMed).

Han, Wang, Huang, Cheng, Sun, Chen, Xie, Zhou, Du: "Isolation and characteristics of CD133‑/A2B5+ and CD133‑/A2B5‑ cells from the SHG139s cell line." in: Molecular medicine reports, Vol. 12, Issue 6, pp. 7949-56, (2016) (PubMed).

Tang, Gao, Mao, He, Liu, Cai, Lin, Wu: "Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways." in: Cell stress & chaperones, Vol. 21, Issue 2, pp. 239-49, (2016) (PubMed).

Ping, Liu, Liu, Li, Zhai, Li, Liu, Li, Wei: "Expression of RKIP, E-cadherin and NF-kB p65 in esophageal squamous cell carcinoma and their correlations." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 10164-70, (2016) (PubMed).

Shan, Lv, Zhao, Liu, Sun, Xi, Xiao, Li: "Wnt/β-catenin pathway is required for epithelial to mesenchymal transition in CXCL12 over expressed breast cancer cells." in: International journal of clinical and experimental pathology, Vol. 8, Issue 10, pp. 12357-67, (2016) (PubMed).

Wang, Chen, Liu, Qu, Lan, Chen, Zou, Qiu: "Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway." in: British journal of cancer, Vol. 114, Issue 3, pp. 305-13, (2016) (PubMed).

Lin, Sun, Wang, Zheng, Zhang, Zheng: "Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition." in: Frontiers in pharmacology, Vol. 6, pp. 320, (2016) (PubMed).

Cheng, Gu, Yuan, Feng, Jia: "Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC-α/ERK1/2 pathway: An in vitro investigation." in: Molecular medicine reports, Vol. 13, Issue 4, pp. 3709-10, (2016) (PubMed).

Ge, Cao, Wang, Sun, Sun, Han, Cui, Liu: "Overexpression of Livin promotes migration and invasion of colorectal cancer cells by induction of epithelial-mesenchymal transition via NF-κB activation." in: OncoTargets and therapy, Vol. 9, pp. 1011-21, (2016) (PubMed).

Li, Chen, Zeng, Li, Zhang, Lin, Zhang, Xie, He, Shu, Yang, Tang, Fu: "Matrigel basement membrane matrix induces eccrine sweat gland cells to reconstitute sweat gland-like structures in nude mice." in: Experimental cell research, Vol. 332, Issue 1, pp. 67-77, (2015) (PubMed).

Deng, Zhang, Zhang, Wen, Miao, Guo: "MicroRNA-142-3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7." in: Tumour biology, (2015) (PubMed).

Su, Li: "RAC1 overexpression promotes the proliferation, migration and epithelial-mesenchymal transition of lens epithelial cells." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 10760-7, (2015) (PubMed).

He, Qian, Cai, Yang, Cai, Wang: "RhoC is essential in TGF-β1 induced epithelial-mesenchymal transition in cervical cancer cells." in: Oncology letters, Vol. 10, Issue 2, pp. 985-989, (2015) (PubMed).

Duan, Lin, Li, Ding, Qian, Zhang, Ge, Fan, Li: "Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells." in: Cancer biology & therapy, Vol. 15, Issue 5, pp. 544-59, (2014) (PubMed).

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抗原

E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))

别名

CDH1 (CDH1 产品)

别名

Arc-1 antibody, CD324 antibody, CDHE antibody, ECAD antibody, LCAM antibody, UVO antibody, E-cadherin antibody, cdh1 antibody, si:dz180o5.2 antibody, uvo antibody, lcam antibody, E-Cad antibody, XBcad antibody, l-cam antibody, xcdh1 antibody, cdhc-A antibody, xb-cad antibody, XTCAD-1 antibody, c-cadherin antibody, cadherin-1 antibody, uvomorulin antibody, XB-cadherin antibody, arc-1 antibody, cd324 antibody, cdhe antibody, ecad antibody, AA960649 antibody, E-cad antibody, Ecad antibody, L-CAM antibody, Um antibody, cadherin 1 antibody, si:busm1-180o5.2 antibody, cadherin 1, type 1, E-cadherin (epithelial) antibody, cadherin 1, type 1 S homeolog antibody, CDH1 antibody, si:busm1-180o5.2 antibody, cdh1 antibody, Cdh1 antibody, cdh1.S antibody

背景

CDH1 (Cadherin 1), also known as ECAD or UVO, is a protein that in humans is encoded by the CDH1 gene. Cadherin-1 is a classical member of the cadherin superfamily. By Southern analysis of DNA from a panel of mouse-human somatic cell hybrids, Mansouri et al. (1987, 1988) assigned the UVO gene to 16q (16p11-qter). Frebourg et al. (2006) found that in human embryos CDH1 is highly expressed at 4 and 5 weeks in the frontonasal prominence and at 6 weeks in the lateral and medial nasal prominences, and is therefore expressed during critical stages of lip and palate development. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.

Synonyms: Arc 1 antibody|CADH1_HUMAN antibody|Cadherin 1 antibody|cadherin 1 type 1 E-cadherin antibody|Cadherin1 antibody|CAM 120/80 antibody|CD 234 antibody|CD 324 antibody|CD324 antibody|CD324 antigen antibody|CDH1 antibody|CDHE antibody|E-Cad/CTF3 antibody|E-cadherin antibody|ECAD antibody|Epithelial cadherin antibody|epithelial calcium dependant adhesion protein antibody|LCAM antibody|Liver cell adhesion molecule antibody|UVO antibody| Uvomorulin antibody

基因ID

999

UniProt

P12830

途径

WNT signaling, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation