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CXCR4 抗体 (N-Term)

Name: CXCR4 抗体 (N-Term)
SKU: ABIN3042911
Availability: OutOfStock

CXCR4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

Anti-CXCR4 antibody, Western blotting Lane 1: M231 Cell Lysate Lane 2: MCF-7 Cell Lysate Lane 3: JURKAT Cell Lysate

1 image

(11 references)

产品编号 ABIN3042911

发货至: 中国

Datasheet as PDF

抗原 See all CXCR4 抗体

CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
抗原表位
24

15

15

12

8

7

6

6

6

5

5

5

5

4

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 31-43, N-Term
适用
148

95

76

22

13

12

11

8

6

6

4

4

3

3

3

3

3

2

1

1

1
人
宿主
126

21

11

6

1
兔
Compatible Secondaries
克隆类型
136

29
多克隆
标记
97

8

8

6

5

4

3

3

3

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1
This CXCR4 antibody is un-conjugated
应用范围
118

55

46

34

31

25

25

25

19

12

8

6

4

4

3

3

2
Western Blotting (WB)

原理

Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 4(CXCR4) detection. Tested with WB in Human.

序列

EENANFNKIF LPT

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 4(CXCR4) detection. Tested with WB in Human.
Gene Name: chemokine(C-X-C motif) receptor 4
Protein Name: C-X-C chemokine receptor type 4

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR4(31-43aa EENANFNKIFLPT).

亚型

IgG

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Discover our top product CXCR4 Primary Antibody
anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 201-294) antibody
CXCR4 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-46) antibody
CXCR4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G9 unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 262-352) antibody
CXCR4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (N-Term) antibody
CXCR4 适用: 人, 小鼠, 兔, Pig, 马 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 14-40) antibody
CXCR4 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 山羊 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-356) antibody
CXCR4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (C-Term) antibody
CXCR4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-46) antibody
CXCR4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F8 unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody (PE)
CXCR4 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 12G5 PE

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 2-15), (Extracellular), (N-Term) antibody
CXCR4 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

有效期

12 months
Zhang, Wang, Yue, Liu, Liu: "Construction of a CXCL12-KDEL fusion gene to inhibit head and neck squamous cell carcinoma metastasis by intracellular sequestration of CXCR4." in: BioMed research international, Vol. 2015, pp. 195828, (2015) (PubMed).

Zhu, Sun, Tan, Xu, Dai, Wang, Fan, Zhou: "Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo." in: Molecular medicine reports, Vol. 10, Issue 2, pp. 585-92, (2015) (PubMed).

Liu, Wang, Wang, Wang: "Anticancer effects of chemokine receptor 4(CXCR4) gene silenced by CXCR4-siRNA in nude mice model of ovarian cancer." in: Cell biochemistry and biophysics, Vol. 70, Issue 3, pp. 1893-900, (2014) (PubMed).

Li, Chen, Yuan, Zhou, He, Zu, Qi: "CXCR4 expression in bladder transitional cell carcinoma and its relationship with clinicopathological features." in: Urologia internationalis, Vol. 92, Issue 2, pp. 157-63, (2014) (PubMed).

Tan, Chang, Liu, Tang: "Silencing of CXCR4 inhibits tumor cell proliferation and neural invasion in human hilar cholangiocarcinoma." in: Gut and liver, Vol. 8, Issue 2, pp. 196-204, (2014) (PubMed).

Wang, Guo, Han, Xu, Guo, Sun: "Distinct roles of different fragments of PDCD4 in regulating the metastatic behavior of B16 melanoma cells." in: International journal of oncology, Vol. 42, Issue 5, pp. 1725-33, (2013) (PubMed).

Chen, Wang, Wang, Zhang, Liu, Pan, Wang, Chen, Jin, Wang: "Effect of short hairpin RNA-induced CXCR4 silence on ovarian cancer cell." in: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 66, Issue 7, pp. 549-53, (2012) (PubMed).

Lin, Zheng, Shen, Tang, Chen, Sun, Zhao, Yao: "Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma." in: Medical oncology (Northwood, London, England), Vol. 28, Issue 2, pp. 649-53, (2011) (PubMed).

Wang, Cai, Han, Yang, Tong, Cao, Wu, Wang: "Silencing of CXCR4 blocks progression of ovarian cancer and depresses canonical Wnt signaling pathway." in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 21, Issue 6, pp. 981-7, (2011) (PubMed).

Li, Deng, Gong, Bian, Dai, Wang: "Upregulation of CXCR4 favoring neural-like cells migration via AKT activation." in: Neuroscience research, Vol. 67, Issue 4, pp. 293-9, (2010) (PubMed).

Zhang, Qi, Li, Zhang, Xu, Wang, Sun: "Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer." in: Journal of experimental & clinical cancer research : CR, Vol. 27, pp. 62, (2009) (PubMed).
抗原

CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

别名

CXCR4 (CXCR4 产品)

别名

CD184 antibody, D2S201E antibody, FB22 antibody, HM89 antibody, HSY3RR antibody, LAP3 antibody, LCR1 antibody, LESTR antibody, NPY3R antibody, NPYR antibody, NPYRL antibody, NPYY3R antibody, WHIM antibody, Cmkar4 antibody, PB-CKR antibody, PBSF/SDF-1 antibody, Sdf1r antibody, CXC-R4-B antibody, CXCR-4-B antibody, cd184 antibody, cxcr4 antibody, fb22 antibody, hm89 antibody, hsy3rr antibody, lap3 antibody, lcr1 antibody, lestr antibody, npy3r antibody, npyr antibody, npyrl antibody, npyy3r antibody, xcxcr4 antibody, CXC-R4 antibody, CXCR-4 antibody, d2s201e antibody, whim antibody, CXC-R4-A antibody, CXCR-4-A antibody, xCXCR4 antibody, CXCR4 antibody, cb403 antibody, zgc:109863 antibody, cb824 antibody, C-X-C motif chemokine receptor 4 antibody, chemokine (C-X-C motif) receptor 4 antibody, C-X-C motif chemokine receptor 4 S homeolog antibody, C-X-C chemokine receptor type 4 antibody, C-X-C motif chemokine receptor 4 L homeolog antibody, chemokine (C-X-C motif), receptor 4b antibody, chemokine (C-X-C motif) receptor 4a antibody, CXCR4 antibody, Cxcr4 antibody, cxcr4.S antibody, cxcr4 antibody, LOC100049444 antibody, cxcr4.L antibody, cxcr4b antibody, cxcr4a antibody

背景

CXCR4 (Chemokine,CXC Motif, Receptor 4), also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. It is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. CXCR4 is the only SDF1 receptor identified so far. This suggests that CXCR4 expression is critical for the biological effects of SDF1. CXCR4 is also a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1. It functions as a co-receptor for T-cell-line tropic human immunodeficiency virus HIV-1. It was concluded that PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization.

Synonyms: C-X-C chemokine receptor type 4 antibody|CD184 antibody|CD184 antigen antibody|Chemokine(C X C motif) receptor 4 antibody|Chemokine CXC Motif Receptor 4 antibody|CXC-R4 antibody|CXCR-4 antibody|CXCR4 antibody|CXCR4_HUMAN antibody|D2S201E antibody|FB22 antibody|Fusin antibody|HM89 antibody|HSY3RR antibody|LAP 3 antibody|LAP3 antibody|LCR1 antibody|LESTR antibody|Leukocyte derived seven transmembrane domain receptor antibody|Leukocyte-derived seven transmembrane domain receptor antibody|Lipopolysaccharide associated protein 3 antibody|Neuropeptide Y receptor Y3 antibody|NPY3R antibody|NPYR antibody|NPYRL antibody|NPYY3 antibody|NPYY3R antibody|Probable G protein coupled receptor lcr1 homolog antibody|SDF 1 receptor antibody|SDF-1 receptor antibody|SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody|Stromal cell derived factor 1 receptor antibody|Stromal cell-derived factor 1 receptor antibody|WHIM antibody

UniProt

P61073

途径

Regulation of Cell Size, CXCR4-mediated Signaling Events