(1 reference)-
- 抗原 See all PPP3CA 抗体
- PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
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抗原表位
- AA 488-521, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PPP3CA antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- Rabbit IgG polyclonal antibody for Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform(PPP3CA) detection. Tested with WB in Human.
- 序列
- DAMPSDANLN SINKALTSET NGTDSNGSNS SNIQ
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
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Rabbit IgG polyclonal antibody for Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform(PPP3CA) detection. Tested with WB in Human.
Gene Name: protein phosphatase 3, catalytic subunit, alpha isozyme
Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Calcineurin A (488-521aa DAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ), different from the related mouse and rat sequences by one amino acid.
- 亚型
- IgG
- Top Product
- Discover our top product PPP3CA Primary Antibody
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anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (AA 1-84) antibody
PPP3CA 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 2G8 unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (Middle Region) antibodyPPP3CA 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, 斑马鱼, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (AA 21-51) antibodyPPP3CA 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) antibodyPPP3CA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) antibodyPPP3CA 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CALNA-2353 unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (N-Term) antibodyPPP3CA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (N-Term) antibodyPPP3CA 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) antibodyPPP3CA 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (AA 432-481) antibodyPPP3CA 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, Pig, 小鸡, 非洲爪蟾, 猴, 豚鼠, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (N-Term) antibodyPPP3CA 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, Pig, 小鸡, 非洲爪蟾, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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: "Buckwheat Rutin Inhibits AngII-induced Cardiomyocyte Hypertrophy via Blockade of CaN-dependent Signal Pathway." in: Iranian journal of pharmaceutical research : IJPR, Vol. 13, Issue 4, pp. 1347-55, (2015) (PubMed).
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: "Buckwheat Rutin Inhibits AngII-induced Cardiomyocyte Hypertrophy via Blockade of CaN-dependent Signal Pathway." in: Iranian journal of pharmaceutical research : IJPR, Vol. 13, Issue 4, pp. 1347-55, (2015) (PubMed).
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- 抗原
- PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
- 别名
- PPP3CA (PPP3CA 产品)
- 别名
- CALN antibody, CALNA antibody, CALNA1 antibody, CCN1 antibody, CNA1 antibody, PPP2B antibody, 2900074D19Rik antibody, AI841391 antibody, AW413465 antibody, CN antibody, Caln antibody, Calna antibody, CnA antibody, Calna1 antibody, calcineurin antibody, caln antibody, calna antibody, calna1 antibody, ccn1 antibody, cna1 antibody, ppp2b antibody, fj46e08 antibody, si:dkeyp-79c2.2 antibody, wu:fj46e08 antibody, ppp3ca antibody, protein phosphatase 3 catalytic subunit alpha antibody, protein phosphatase 3, catalytic subunit, alpha isoform antibody, protein phosphatase 3, catalytic subunit, alpha isozyme antibody, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) antibody, protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog antibody, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody, PPP3CA antibody, Ppp3ca antibody, ppp3ca antibody, ppp3ca.L antibody, LOC100205420 antibody
- 背景
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Calcineurin A is also known as PPP3CA. It is mapped to 4q24. Semsarian et al. (1999) and Musaro et al. (1999) independently showed that IGF1stimulates skeletal muscle hypertrophy and a switch to glycolytic metabolism by activating calcineurin A and inducing the nuclear translocation of transcription factor NFATC1. Semsarian et al. (1999) found that hypertrophy was suppressed by the calcineurin inhibitors cyclosporin A or FK506, but not by inhibitors of the MAP kinase or phosphatidylinositol-3-OH kinase pathways. Musaro et al. (1999) showed that expression of a dominant-negative calcineurin mutant also repressed myocyte differentiation and hypertrophy. Musaro et al. (1999) demonstrated that either IGF1 or activated calcineurin induces expression of transcription factor GATA2, which accumulates in a subset of myocyte nuclei, where it associates with calcineurin and a specific dephosphorylated isoform of NFATC1.
Synonyms: Alpha isoform formerly PPP2B antibody|Calcineurin A alpha antibody|Calcineurin A1 antibody|CalcineurinA antibody|Calmodulin dependent calcineurin A subunit alpha isoform antibody|Calmodulin-dependent calcineurin A subunit alpha isoform antibody|CALN antibody|CALNA 1 antibody|CALNA antibody|CALNA1 antibody|CAM PRP catalytic subunit antibody|CAM-PRP catalytic subunit antibody|CCN 1 antibody|CCN1 antibody|CNA 1 antibody|CNA alpha antibody|CNA antibody|CNA1 antibody|FLJ26613 antibody|MGC52248 antibody|PP2BA_HUMAN antibody|PPP2B antibody|PPP3CA antibody|Protein phosphatase 2B catalytic subunit antibody|Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform antibody|Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA antibody|Protein phosphatase 3 catalytic subunit alpha isozyme antibody|Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform antibody|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody - 基因ID
- 5530
- UniProt
- Q08209
- 途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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