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COL4a2 抗体 (C-Term)

Name: COL4a2 抗体 (C-Term)
SKU: ABIN3042317
Availability: OutOfStock

COL4A2 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

Anti-Collagen IV antibody, Western blotting Lane 1: Rat Kidney Tissue Lysate Lane 2: Rat Lung Tissue Lysate

Anti-Collagen IV antibody, IHC(F) IHC(F): Rat Kidney Tissue

IHC

Anti-Collagen IV antibody, IHC(P) IHC(P): Mouse Lung Tissue

IHC

3 images

(13 references)

产品编号 ABIN3042317

发货至: 中国

Datasheet as PDF

抗原 See all COL4a2 (COL4A2) 抗体

COL4a2 (COL4A2) (Collagen, Type IV, alpha 2 (COL4A2))
抗原表位
15

12

8

7

5

2

2

1

1

1

1
AA 1697-1712, C-Term

适用

人, 小鼠, 大鼠
宿主
47
兔
Compatible Secondaries
克隆类型
47
多克隆
标记
19

5

4

4

2

2

1

1

1

1

1

1

1

1

1

1

1
This COL4a2 antibody is un-conjugated
应用范围
42

24

14

13

13

11

6

5

3

2

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

原理

Rabbit IgG polyclonal antibody for Collagen alpha-2(IV) chain(COL4A2) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.

序列

LIRTHISRCQ VCMKNL

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Collagen alpha-2(IV) chain(COL4A2) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.
Gene Name: collagen, type IV, alpha 2
Protein Name: Collagen alpha-2(IV) chain

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen IV(1697-1712aa LIRTHISRCQVCMKNL), identical to the related rat and mouse sequences.

亚型

IgG

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COL4A2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type IV, alpha 2 (COL4A2) (N-Term) antibody
COL4A2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type IV, alpha 2 (COL4A2) (AA 1487-1703) antibody
COL4A2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type IV, alpha 2 (COL4A2) antibody
COL4A2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type IV, alpha 2 (COL4A2) (N-Term) antibody
COL4A2 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type IV, alpha 2 (COL4A2) (AA 151-200) antibody
COL4A2 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type IV, alpha 2 (COL4A2) (AA 1493-1712) antibody
COL4A2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type IV, alpha 2 (COL4A2) (AA 1486-1712) antibody
COL4A2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type IV, alpha 2 (COL4A2) antibody
COL4A2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type IV, alpha 2 (COL4A2) (AA 156-186), (N-Term) antibody
COL4A2 适用: 小鼠 WB, FACS 宿主: 兔 Polyclonal RB18892 unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

有效期

12 months
Zhu, Chen, Chen, Yang, Xie: "Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats." in: Journal of diabetes research, Vol. 2018, pp. 6730315, (2018) (PubMed).

Luo, Deng, Lamsal, Xu, Xiang, Cheng: "AMP-activated protein kinase alleviates extracellular matrix accumulation in high glucose-induced renal fibroblasts through mTOR signaling pathway." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 35, Issue 1, pp. 191-200, (2015) (PubMed).

Qiu, Zhang, Zhao, Zhang, Wu, Guo, Hu: "Enhancement of endothelial differentiation of adipose derived mesenchymal stem cells by a three-dimensional culture system of microwell." in: Biomaterials, Vol. 53, pp. 600-8, (2015) (PubMed).

Liu, Lu, Li, Wei, Li: "Engineering blood vessels through micropatterned co-culture of vascular endothelial and smooth muscle cells on bilayered electrospun fibrous mats with pDNA inoculation." in: Acta biomaterialia, Vol. 11, pp. 114-25, (2014) (PubMed).

Ji, Wu, Ma, Ma, Qin: "The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic nephropathy." in: Molecular biology reports, Vol. 41, Issue 4, pp. 2151-9, (2014) (PubMed).

Wenbin, Guojun: "Resveratrol Ameliorates Diabetes-induced Renal Damage through Regulating the Expression of TGF-?1, Collagen IV and Th17/Treg-related Cytokines in Rats." in: The West Indian medical journal, Vol. 63, Issue 1, pp. 20-5, (2014) (PubMed).

Chen, Wan, Xia, Guo, Wang, Liu, Li: "Promoted regeneration of mature blood vessels by electrospun fibers with loaded multiple pDNA-calcium phosphate nanoparticles." in: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fu?r Pharmazeutische Verfahrenstechnik e.V, Vol. 85, Issue 3 Pt A, pp. 699-710, (2013) (PubMed).

Xu, Zheng, He, Li, Zhang, Liang: "Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-?1/Smad signaling pathway, thereby leading to anti-fibrotic effect." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 20, Issue 13, pp. 1172-9, (2013) (PubMed).

Wen, Huang, Zhang, Zhang, Chen, Gu, Hao: "Resveratrol attenuates diabetic nephropathy via modulating angiogenesis." in: PLoS ONE, Vol. 8, Issue 12, pp. e82336, (2013) (PubMed).

He, Xia, Wang, Wei, Luo, Li: "Multiple release of polyplexes of plasmids VEGF and bFGF from electrospun fibrous scaffolds towards regeneration of mature blood vessels." in: Acta biomaterialia, Vol. 8, Issue 7, pp. 2659-69, (2012) (PubMed).

Qi, Kai-Chen, Liu, Su, Yu: "Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor ?1 and type IV collagen expression in rats." in: Journal of ethnopharmacology, Vol. 138, Issue 3, pp. 731-6, (2011) (PubMed).

Zhang, Wu, Zheng, Li: "Adenovirus-mediated decorin gene transfection has therapeutic effects in a streptozocin-induced diabetic rat model." in: Nephron. Experimental nephrology, Vol. 116, Issue 1, pp. e11-21, (2010) (PubMed).

Xue, Zhang, Liu, Wang: "A new ATP-sensitive potassium channel opener protects the kidney from hypertensive damage in spontaneously hypertensive rats." in: The Journal of pharmacology and experimental therapeutics, Vol. 315, Issue 2, pp. 501-9, (2005) (PubMed).
抗原

COL4a2 (COL4A2) (Collagen, Type IV, alpha 2 (COL4A2))

别名

COL4A2 (COL4A2 产品)

别名

col4a2-a antibody, zCanstatin antibody, ICH antibody, POREN2 antibody, Col4a-2 antibody, collagen, type IV, alpha 2 L homeolog antibody, collagen type IV alpha 2 chain antibody, collagen, type IV, alpha 2 antibody, col4a2.L antibody, COL4A2 antibody, col4a2 antibody, Col4a2 antibody

背景

Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Synonyms: Arresten antibody|Canstatin antibody|CO4A1_HUMAN antibody|COL4A1 antibody|COL4A1 NC1 domain antibody|COL4A2 antibody|COL4A3 antibody|COL4A4 antibody|COL4A5 antibody|Collagen Alpha 1(IV) Chain antibody|Collagen Alpha 2(IV) Chain antibody|collagen alpha-1(IV) chain antibody|Collagen IV Alpha 1 Polypeptide antibody|Collagen IV Alpha 2 Polypeptide antibody|Collagen Of Basement Membrane Alpha 1 Chain antibody|Collagen Of Basement Membrane Alpha 2 Chain antibody|Collagen Type IV Alpha 1 antibody|Collagen Type IV Alpha 2 antibody|Collagen Type IV Alpha 3 antibody|Collagen Type IV Alpha 4 antibody|Collagen Type IV Alpha 5 antibody|DKFZp686I14213 antibody|FLJ22259 antibody

UniProt

P08572