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DLG4 抗体 (C-Term)

DLG4 适用: 大鼠, 小鼠, 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3030742
发货至: 中国
  • 抗原 See all DLG4 抗体
    DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))
    抗原表位
    • 16
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    C-Term
    适用
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    大鼠, 小鼠, 人
    宿主
    • 121
    • 63
    • 1
    • 1
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    克隆类型
    • 114
    • 73
    多克隆
    标记
    • 65
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    This DLG4 antibody is un-conjugated
    应用范围
    • 124
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    Antigen affinity
    免疫原
    An amino acid sequence from the C-terminus of human PSD-95 (RRVERREWSRLKAKDW) was used as the immunogen for this PSD-95 antibody (100% homologous in human, mouse and rat).
    亚型
    IgG
    Top Product
    Discover our top product DLG4 Primary Antibody
  • 应用备注
    The stated application concentrations are suggested starting amounts. Titration of the PSD-95 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the PSD-95 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))
    别名
    PSD-95 (PSD95) (DLG4 产品)
    背景
    DLG4 (Discs large homolog 4), also known as Post-synaptic density protein 95 (PSD-95) or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase (MAGUK) family. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity.
    UniProt
    P78352
    途径
    Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity
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