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- 抗原 See all MAML3 抗体
- MAML3 (Mastermind-Like 3 (MAML3))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MAML3 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Protein G affinity chromatography
- 免疫原
- A human full length recombinant protein was used as the immunogen for this MAML3 antibody.
- 克隆位点
- MMLP3-1
- 亚型
- IgG1
- Top Product
- Discover our top product MAML3 Primary Antibody
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anti-Mastermind-Like 3 (MAML3) antibody
MAML3 适用: 人 ISt, IHC, StM 宿主: 小鼠 Monoclonal MAML3-1303 unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal MAML3-1303 unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 1024-1131) antibodyMAML3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 640-665), (C-Term) antibodyMAML3 适用: 人 FACS, WB, IHC (p) 宿主: 兔 Polyclonal RB18761 unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 FACS, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 791-840) antibodyMAML3 适用: 人, 小鼠, 马, 兔, 犬, 豚鼠, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal MAML3-1303 unconjugated
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- 应用备注
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The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MAML3 antibody to be titered up or down for optimal performance.
1. Staining of FFPE tissue requires boiling sections in 10 mM Tris with 1 mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.\. FACS: 0.5-1 μg/10^6 cells,IF: 1-2 μg/mL,IHC (FFPE): 0.5-1 μg/mL (1)
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
- 储存液
- Azide free
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store the MAML3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- 抗原
- MAML3 (Mastermind-Like 3 (MAML3))
- 别名
- MAML3 (MAML3 产品)
- 别名
- AV234550 antibody, BC049812 antibody, Mam-2 antibody, mKIAA1816 antibody, Glrp1 antibody, CAGH3 antibody, ERDA3 antibody, GDN antibody, MAM-2 antibody, MAM2 antibody, TNRC3 antibody, mastermind like 3 (Drosophila) antibody, mastermind-like transcriptional coactivator 3 antibody, mastermind like transcriptional coactivator 3 antibody, Maml3 antibody, MAML3 antibody
- 背景
- Mastermind-like 3 is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch 1-4 proteins. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, its upregulation is thought to be involved in oncogenesis.
- 基因ID
- 55534
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