RGD1566110 antibody, CLEC1 antibody, 5930406N14Rik antibody, C-type lectin domain family 1, member A antibody, C-type lectin domain family 1 member A antibody, C-type lectin domain family 1, member a antibody, Clec1a antibody, CLEC1A antibody
背景
CLEC1 is a C-type lectin receptor and part of the 'Dectin-1 cluster' subfamily which also includes Dectin-1, LOX-1, CLEC-2, MICL, CLEC12B, and CLEC9A. Similar to other family members, CLEC1 displays N-liked glycosylation and dimerization characteristics, and is found on dendritic cells, monocytes and granulocytes. However, unlike other family members, CLEC1 expression level is upregulated by IL-10 and TGFb, but not by pro-inflammatory stimuli, and it is expressed on endothelial cells. Enhanced expression at allograft sites suggests CLEC1 may have an immune-regulatory function and may support allograft tolerance.