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Histone 3 抗体 (H3K9me2)

H3 适用: 人 WB, IHC, IF, ChIP, IP, ChIP-seq 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3023260
发货至: 中国
  • 抗原 See all Histone 3 (H3) 抗体
    Histone 3 (H3)
    抗原表位
    • 59
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    H3K9me2
    适用
    • 1396
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    • 861
    • 59
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    宿主
    • 1214
    • 243
    • 8
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    克隆类型
    • 1120
    • 348
    • 1
    多克隆
    标记
    • 818
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    This Histone 3 antibody is un-conjugated
    应用范围
    • 1055
    • 411
    • 377
    • 311
    • 249
    • 188
    • 181
    • 178
    • 163
    • 161
    • 142
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP), Immunoprecipitation (IP), ChIP DNA-Sequencing (ChIP-seq)
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Methylated Antibodies
    纯化方法
    Affinity purification
    免疫原
    A synthetic methylated peptide corresponding to residues surrounding K9 of human histone H3
    亚型
    IgG
    Top Product
    Discover our top product H3 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200,ChIP,1:50 - 1:200,ChIP-seq,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid freeze / thaw cycles
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • Zuo, Rong, Li, Lv, Lan, Tong: "The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice." in: The Journal of biological chemistry, Vol. 293, Issue 24, pp. 9188-9197, (2019) (PubMed).

    Vaughan, Dickson, Whelihan, Johnstone, Cornett, Cheek, Ausherman, Cowles, Sun, Rothbart: "Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 35, pp. 8775-8780, (2018) (PubMed).

    Cao, Liu, Yue, Liu, Pei, Gu, Wang, Jia: "Iron chelation inhibits cancer cell growth and modulates global histone methylation status in colorectal cancer." in: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, Vol. 31, Issue 5, pp. 797-805, (2018) (PubMed).

    Zhao, Lei, Zhang, Zheng, Wang, Zhao, Li, Ye, Li, Wei, Wu: "Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model." in: Clinical epigenetics, Vol. 8, pp. 34, (2016) (PubMed).

  • 抗原
    Histone 3 (H3)
    别名
    Histone H3 (H3 产品)
    别名
    H-3 antibody, histocompatibility 3 antibody, H3 antibody
    背景
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.,H3.4,H3/g,H3FT,H3t,HIST3H3,Histone H3,HIST1H3A,Signal Transduction,MAPK-Erk Signaling Pathway,MAPK-P38 Signaling Pathway,Epigenetics & Nuclear Signaling,Epigenetic Modifications,Methylation,Histone H3
    分子量
    15 kDa
    基因ID
    8290
    UniProt
    Q16695
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