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Glucocorticoid Receptor 抗体 (AA 1-280)

Name: Glucocorticoid Receptor 抗体 (AA 1-280)
Brand: antibodies-online
SKU: ABIN3023091
Availability: OutOfStock

NR3C1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts of various cell lines, using NR3C1 antibody.

Immunofluorescence analysis of PC-12 cells using Glucocorticoid Receptor Rabbit pAb (ABIN3023090, ABIN3023091, ABIN3023092, ABIN1513281 and ABIN6219384) at dilution of 1:200 (40x lens).

Immunohistochemistry (IHC) image for anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 1-280) antibody (ABIN3023091)

IHC

Immunohistochemistry of paraffin-embedded rat spleen using Glucocorticoid Receptor Rabbit pAb (ABIN3023090, ABIN3023091, ABIN3023092, ABIN1513281 and ABIN6219384) at dilution of 1:100 (40x lens).

IHC

Immunohistochemistry of paraffin-embedded human liver cancer using Glucocorticoid Receptor Rabbit pAb (ABIN3023090, ABIN3023091, ABIN3023092, ABIN1513281 and ABIN6219384) at dilution of 1:100 (40x lens).

IHC

Immunofluorescence analysis of NIH/3T3 cells using Glucocorticoid Receptor Rabbit pAb (ABIN3023090, ABIN3023091, ABIN3023092, ABIN1513281 and ABIN6219384) at dilution of 1:200 (40x lens).

6 images

(3 references)

产品编号 ABIN3023091

发货至: 中国

Datasheet as PDF

抗原 See all Glucocorticoid Receptor (NR3C1) 抗体

Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))
抗原表位
21

17

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14

13

7

7

6

6

6

6

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3

3

3

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2

2

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2

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1

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AA 1-280
适用
160

90

65

8

5

3

3

3

3

3

1

1

1

1
人
宿主
156

15

3
兔
Compatible Secondaries
克隆类型
147

27
多克隆
标记
77

20

14

10

8

6

4

4

4

4

4

4

3

3

3

3

3
This Glucocorticoid Receptor antibody is un-conjugated
应用范围
158

74

60

42

39

39

35

26

25

15

11

5

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

序列

MDSKESLTPG REENPSSVLA QERGDVMDFY KTLRGGATVK VSASSPSLAV ASQSDSKQRR LLVDFPKGSV SNAQQPDLSK AVSLSMGLYM GETETKVMGN DLGFPQQGQI SLSSGETDLK LLEESIANLN RSTSVPENPK SSASTAVSAA PTEKEFPKTH SDVSSEQQHL KGQTGTNGGN VKLYTTDQST FDILQDLEFS SGSPGKETNE SPWRSDLLID ENCLLSPLAG EDDSFLLEGN SNEDCKPLIL PDTKPKIKDN GDLVLSSPSN VTLPQVKTEK

交叉反应

人, 小鼠, 大鼠

产品特性

Polyclonal Antibodies

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human Glucocorticoid Receptor (NP_001191194.1).

亚型

IgG
anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 51-140) antibody
NR3C1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C8 unconjugated

anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (N-Term) antibody
KO Validated NR3C1 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) antibody
NR3C1 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 6-00E-06 unconjugated

anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 231-320) antibody
NR3C1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 598-755) antibody
NR3C1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (Ser211) antibody
NR3C1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 1-190) antibody
NR3C1 适用: 人 WB, IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 1-373) antibody
NR3C1 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (pSer211) antibody
NR3C1 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (Ser226), (Ser234), (Ser246) antibody
NR3C1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze / thaw cycles

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Liu, Chen, Pei, Zhang, Zou, Xiao, Zhou, Chen, Wang: "Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats." in: Toxicology, Vol. 408, pp. 1-10, (2018) (PubMed).

Zhang, Yao, Xiao, Lan, Yu, Zhang, Jiang, Yang, Pei, Li, Rong, Hu, Li, Xu: "Administration of dexamethasone protects mice against ischemia/reperfusion induced renal injury by suppressing PI3K/AKT signaling." in: International journal of clinical and experimental pathology, Vol. 6, Issue 11, pp. 2366-75, (2014) (PubMed).

Zhang, Li, Wang, Han, Xiao, Lan, Li, Xu, Yao: "Glucocorticoid receptor agonist dexamethasone attenuates renal ischemia/reperfusion injury by up-regulating eNOS/iNOS." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 34, Issue 4, pp. 516-520, (2014) (PubMed).
抗原

Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

别名

NR3C1 (NR3C1 产品)

别名

GR antibody, gcr antibody, grl antibody, xGR antibody, gccr antibody, gr antibody, zgc:113038 antibody, NR3C1 antibody, GCL antibody, LOC100302444 antibody, Gcr antibody, Grl antibody, Grl-1 antibody, Grl1 antibody, GRL antibody, GCCR antibody, GCR antibody, NO antibody, GR-A antibody, nr3c1 antibody, nuclear receptor subfamily 3 group C member 1 antibody, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) antibody, nuclear receptor subfamily 3, group C, member 1 antibody, glucocorticoid receptor antibody, NR3C1 antibody, nr3c1 antibody, LOC100302444 antibody, Nr3c1 antibody

背景

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).,GCCR,GCR,GCRST,GR,GRL,NR3C1,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Nuclear hormone receptors,Signal Transduction,NR3C1

分子量

49-85 kDa

基因ID

2908

UniProt

P04150

途径

Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process