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CXCR7 抗体

KO Validated CXCR7 适用: 人 WB, ELISA, FACS, IHC (p), IF, IHC (fro), IP, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2857021
发货至: 中国
  • 抗原 See all CXCR7 抗体
    CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))
    适用
    • 100
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    宿主
    • 86
    • 13
    • 1
    克隆类型
    • 76
    • 23
    • 1
    多克隆
    标记
    • 41
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    This CXCR7 antibody is un-conjugated
    应用范围
    • 74
    • 35
    • 35
    • 18
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    • 13
    • 8
    • 5
    • 3
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    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    交叉反应
    人, 小鼠
    产品特性
    Rabbit Polyclonal antibody to CXCR7 (C-X-C chemokine receptor type 7)
    CXCR7 antibody [C1C2], Internal
    纯化方法
    Purified by antigen-affinity chromatography.
    质量等级
    KO Validated
    免疫原
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human CXCR7. The exact sequence is proprietary.
    亚型
    IgG
  • 应用备注
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Validatio: KO/KD, Orthogonal

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.92 mg/mL
    缓冲液
    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Wei, Huang, Hsieh, Lin, Shyu, Chen, Hsieh: "Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling." in: Cell death & disease, Vol. 11, Issue 5, pp. 307, (2020) (PubMed).

    Liu, Song, Setroikromo, Chen, Hu, Chen, van der Wekken, Melgert, Timens, van den Berg, Saber, Haisma: "CX Chemokine Receptor 7 Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor." in: Cancers, Vol. 11, Issue 4, (2019) (PubMed).

    Xu, Tang, Wang, Liu, Fu, Luo: "CXCR7 promotes melanoma tumorigenesis via Src kinase signaling." in: Cell death & disease, Vol. 10, Issue 3, pp. 191, (2019) (PubMed).

    Tam, Ko, Koon, Cheng, Lok, Lau, Leung, Fung, Chan, Lau: "Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula." in: PLoS ONE, Vol. 10, Issue 10, pp. e0139342, (2016) (PubMed).

    Liu, Carson-Walter, Walter: "Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells." in: PLoS ONE, Vol. 9, Issue 8, pp. e103938, (2015) (PubMed).

    Salazar, Muñoz, Kallifatidis, Singh, Jordà, Lokeshwar: "The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation." in: Molecular cancer, Vol. 13, pp. 198, (2014) (PubMed).

    Singh, Lokeshwar: "The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth." in: Cancer research, Vol. 71, Issue 9, pp. 3268-77, (2011) (PubMed).

  • 抗原
    CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))
    别名
    atypical chemokine receptor 3 (CXCR7 产品)
    别名
    CMKOR1 antibody, CXC-R7 antibody, CXCR-7 antibody, CXCR7 antibody, GPR159 antibody, RDC-1 antibody, RDC1 antibody, AW541270 antibody, Cmkor1 antibody, Cxcr7 antibody, Rdc1 antibody, ackr3 antibody, cxcr7 antibody, rdc1 antibody, xcxcr7 antibody, atypical chemokine receptor 3 antibody, ORF 74; similar to Kaposi's sarcoma-associated herpesvirus ORF 74 antibody, atypical chemokine receptor 3 L homeolog antibody, ACKR3 antibody, MmrVgp88 antibody, Ackr3 antibody, ackr3.L antibody
    背景
    This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.

    Cellular Localization: Cell membrane
    分子量
    41 kDa
    基因ID
    57007
    UniProt
    P25106
    途径
    Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling
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