ZC3H12A 抗体
-
- 抗原 See all ZC3H12A 抗体
- ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This ZC3H12A antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- 特异性
- Knockdown/Knockout validation was supported by references (PMID:27322373)
- 交叉反应
- 人
- 产品特性
-
Rabbit Polyclonal antibody to ZC3H12A (zinc finger CCCH-type containing 12A)
ZC3H12A antibody [N3C3] - 纯化方法
- Purified by antigen-affinity chromatography.
- 质量等级
- KO Validated
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human ZC3H12A. The exact sequence is proprietary.
- 亚型
- IgG
-
-
- 应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 说明
-
Validatio: KO/KD, Orthogonal
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1.8 mg/mL
- 缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
-
Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression." in: Cellular signalling, Vol. 50, pp. 1-8, (2019) (PubMed).
: "Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury." in: Signal transduction and targeted therapy, Vol. 2, pp. 17066, (2017) (PubMed).
: "MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-κB." in: Molecular and cellular biochemistry, Vol. 395, Issue 1-2, pp. 253-63, (2015) (PubMed).
: "Proteasome inhibitor MG-132 induces MCPIP1 expression." in: The FEBS journal, Vol. 280, Issue 11, pp. 2665-74, (2013) (PubMed).
: "MCP-induced protein 1 suppresses TNFalpha-induced VCAM-1 expression in human endothelial cells." in: FEBS letters, Vol. 584, Issue 14, pp. 3065-72, (2010) (PubMed).
: "
-
Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression." in: Cellular signalling, Vol. 50, pp. 1-8, (2019) (PubMed).
-
- 抗原
- ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))
- 别名
- zinc finger CCCH-type containing 12A (ZC3H12A 产品)
- 别名
- CGA antibody, MCPIP antibody, MCPIP1 antibody, RP3-423B22.1 antibody, dJ423B22.1 antibody, BC036563 antibody, Mcpip1 antibody, RGD1306776 antibody, chromogranin A antibody, zinc finger CCCH-type containing 12A antibody, zinc finger CCCH type containing 12A antibody, CHGA antibody, ZC3H12A antibody, Zc3h12a antibody
- 背景
-
ZC3H12A is an MCP1 (CCL2, MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM]
Cellular Localization: Cytoplasm (By similarity) , Nucleus - 分子量
- 66 kDa
- 基因ID
- 80149
- UniProt
- Q5D1E8
- 途径
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of fat Cell Differentiation
-