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- 抗原 See all HLA-DRB3 抗体
- HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HLA-DRB3 antibody is un-conjugated
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应用范围
- Immunofluorescence (IF), Immunocytochemistry (ICC)
- 交叉反应
- 人
- 产品特性
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Rabbit Polyclonal antibody to HLA-DRB3 (major histocompatibility complex, class II, DR beta 3)
HLA-DRB3 antibody - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human HLA-DRB3. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product HLA-DRB3 Primary Antibody
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anti-Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3) (AA 1-266) antibody
HLA-DRB3 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3) antibodyHLA-DRB3 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3) (AA 111-227) antibodyHLA-DRB3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3) (AA 1-266) antibodyHLA-DRB3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3) antibodyHLA-DRB3 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3) antibodyHLA-DRB3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3) (AA 150-199) antibodyHLA-DRB3 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3) (AA 30-227) antibodyHLA-DRB3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- 抗原
- HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))
- 别名
- major histocompatibility complex, class II, DR beta 3 (HLA-DRB3 产品)
- 别名
- HLA-DR3B antibody, BLA-DRB3 antibody, Bota-DRB01 antibody, Bota-DRB02 antibody, Bota-DRB04 antibody, Bota-DRB07 antibody, Bota-DRB21 antibody, Bota-DRB22 antibody, LA-DRB antibody, major histocompatibility complex, class II, DR beta 3 antibody, major histocompatibility complex, class II, DRB3 antibody, HLA-DRB3 antibody, BOLA-DRB3 antibody
- 背景
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HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Cellular Localization: Membrane - 分子量
- 30 kDa
- 基因ID
- 3125
- UniProt
- P79483
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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