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c-MYC 抗体 (Center)

Name: c-MYC 抗体 (Center)
Brand: antibodies-online
SKU: ABIN2855631
Availability: OutOfStock

MYC 适用: 人, 小鼠 WB, IF, IP, ICC, ChIP 宿主: 兔 Polyclonal unconjugated

WB Image Sample (whole cell lysate) A: 293T 20ug B: 293T 10ug 10% SDS PAGE antibody diluted at 1:1000

ICC/IF Image c-Myc antibody detects c-Myc protein at nucleus by immunofluorescent analysis.

WB Image c-Myc antibody detects c-Myc protein by western blot analysis.

IP Image c-Myc antibody immunoprecipitates c-Myc protein in IP experiments.

ChIP

WB Image Sample (30 ug of whole cell lysate) A: NIH-3T3 B: Raw264.

(A) Effect of macrophage CM on mRNA and protein expression of β-catenin down-stream genes.

8 images

(5 references)

产品编号 ABIN2855631

发货至: 中国

Datasheet as PDF

抗原 See all c-MYC (MYC) 抗体

c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
抗原表位
55

44

43

40

24

21

19

16

15

11

11

11

10

7

7

6

6

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
Center
适用
372

169

123

15

14

13

13

13

9

9

8

6

6

6

5

4

3

3

2

2

2

1

1

1

1

1
人, 小鼠
宿主
294

97

7

3

2

1
兔
Compatible Secondaries
克隆类型
287

116
多克隆
标记
193

32

27

26

10

9

9

9

9

9

9

7

5

5

5

5

5

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1
This c-MYC antibody is un-conjugated
应用范围
303

142

96

83

79

64

57

28

26

16

14

13

12

11

7

4

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)

交叉反应

Chimpanzee

交叉反应（详细）

Chimpanzee (100 %)

产品特性

Rabbit Polyclonal antibody to c-Myc (v-myc myelocytomatosis viral oncogene homolog (avian))
c-Myc antibody

纯化方法

Purified by antigen-affinity chromatography.

免疫原

Recombinant protein encompassing a sequence within the center region of human c-Myc. The exact sequence is proprietary.

亚型

IgG

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应用备注

Suggested dilution Reference ChIP assay Assay-dependent dilution ICC/IF 1:100-1:1000* Immunoprecipitation 1:100-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceChIP assayAssay-dependent dilution ICC/IF1:100-1:1000* Immunoprecipitation1:100-1:500* Western blot1:500-1:3000*

说明

Positive Control: 293T , NIH-3T3 , Raw264.7 , HeLa , HeLa nuclear extract

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

1XPBS, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

储存液

Thimerosal (Merthiolate)

注意事项

This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Chen, Ding, Chen, Hu, Lu, Wu, Zhang, Yang, Wu, Peng, Xie, Zhou, Wu, Zheng: "ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis." in: Oncogenesis, Vol. 9, Issue 4, pp. 42, (2020) (PubMed).

Seira, Yamagata, Fukushima, Araki, Kurata, Yanagisawa, Mashimo, Nakamura, Regan, Murayama, Fujino: "Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region." in: Pharmacology research & perspectives, Vol. 6, Issue 6, pp. e00441, (2019) (PubMed).

Ma, Wang, Chen, Li, Hur, Saijilafu: "Differential Roles of Glycogen Synthase Kinase 3 Subtypes Alpha and Beta in Cortical Development." in: Frontiers in molecular neuroscience, Vol. 10, pp. 391, (2017) (PubMed).

Chung, Liu, Lin, Chi, Huang, Yang, Yeh, Tan, Lin: "ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance." in: Oncotarget, Vol. 7, Issue 16, pp. 22448-59, (2017) (PubMed).

Wu, Lee, Hua, Kuo, Lin: "Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the β-Catenin Pathway." in: PLoS ONE, Vol. 10, Issue 7, pp. e0134122, (2016) (PubMed).
抗原

c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

别名

C-Myc (MYC 产品)

别名

MRTL antibody, MYCC antibody, bHLHe39 antibody, c-Myc antibody, CMYC antibody, c-myc antibody, C-MYC antibody, LOC100136746 antibody, ARC antibody, B430311C09Rik antibody, MYC antibody, NOP antibody, Nop30 antibody, RNCMYC antibody, mMyc antibody, AU016757 antibody, Myc2 antibody, Niard antibody, Nird antibody, cmyc antibody, zc-myc antibody, c-myc II antibody, myc-B antibody, myc2 antibody, myc1 antibody, CMyc antibody, zgc:55680 antibody, CG10798 antibody, D-Myc antibody, DM antibody, DMYc antibody, Dm antibody, Dmel\CG10798 antibody, Dmyc antibody, EG:BACN5I9.1 antibody, anon-WO03040301.171 antibody, bHLHe57 antibody, c-MYC antibody, d-myc antibody, dMYC antibody, dMyc antibody, dMyc1 antibody, da antibody, dm antibody, dm/dMyc antibody, dm/myc antibody, dmyc antibody, dmyc1 antibody, l(1)G0139 antibody, l(1)G0354 antibody, l(1)G0359 antibody, myc antibody, MYC proto-oncogene, bHLH transcription factor antibody, v-myc myelocytomatosis viral oncogene homolog antibody, nucleolar protein 3 (apoptosis repressor with CARD domain) antibody, myelocytomatosis oncogene antibody, MYC proto-oncogene, bHLH transcription factor a antibody, MYC proto-oncogene, bHLH transcription factor L homeolog antibody, MYC proto-oncogene, bHLH transcription factor S homeolog antibody, v-myc myelocytomatosis viral oncogene homolog (avian) antibody, MYC proto-oncogene, bHLH transcription factor b antibody, CG10798 gene product from transcript CG10798-RB antibody, MYC antibody, LOC100136746 antibody, Nol3 antibody, Myc antibody, myca antibody, myc.L antibody, myc.S antibody, mycb antibody

背景

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Cellular Localization: Nucleus

分子量

49 kDa

基因ID

4609

途径

p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect