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ACTN2 抗体

ACTN2 适用: 人 WB, IHC, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2855582
发货至: 中国
  • 抗原 See all ACTN2 抗体
    ACTN2 (Actinin, alpha 2 (ACTN2))
    适用
    • 64
    • 51
    • 34
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    宿主
    • 75
    • 11
    克隆类型
    • 65
    • 21
    多克隆
    标记
    • 41
    • 8
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    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ACTN2 antibody is un-conjugated
    应用范围
    • 67
    • 21
    • 21
    • 14
    • 13
    • 13
    • 10
    • 8
    • 7
    • 4
    • 3
    • 3
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    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    特异性
    Based on sequence homology, this antibody may cross-react with other Actinin family members.
    交叉反应
    人, 小鼠, Pig, 大鼠, 斑马鱼
    产品特性
    Rabbit Polyclonal antibody to alpha Actinin 2 (actinin, alpha 2)
    alpha Actinin 2 antibody [N1N3]
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human alpha Actinin 2. The exact sequence is proprietary.
    亚型
    IgG
  • 应用备注
    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.18 mg/mL
    缓冲液
    1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Roberts, Romero, Mobley, Mumford, Roberson, Haun, Vann, Osburn, Holmes, Greer, Lockwood, Parry, Kavazis: "Skeletal muscle mitochondrial volume and myozenin-1 protein differences exist between high versus low anabolic responders to resistance training." in: PeerJ, Vol. 6, pp. e5338, (2018) (PubMed).

  • 抗原
    ACTN2 (Actinin, alpha 2 (ACTN2))
    别名
    actinin alpha 2 (ACTN2 产品)
    别名
    MGC89234 antibody, ACTN2 antibody, 1110008F24Rik antibody, CMD1AA antibody, wu:fd44c03 antibody, zgc:123223 antibody, actinin alpha 2 antibody, actinin, alpha 2b antibody, actinin alpha 2 S homeolog antibody, actn2 antibody, ACTN2 antibody, Actn2 antibody, actn2b antibody, actn2.S antibody
    背景
    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.

    Cellular Localization: Cytoplasm , myofibril , sarcomere , Z-disk
    分子量
    104 kDa
    基因ID
    88
    UniProt
    P35609
    途径
    Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
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