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Amphiregulin 抗体

AREG 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2854897
发货至: 中国
  • 抗原 See all Amphiregulin (AREG) 抗体
    Amphiregulin (AREG)
    适用
    • 32
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    宿主
    • 27
    • 9
    • 1
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    克隆类型
    • 31
    • 8
    多克隆
    标记
    • 27
    • 3
    • 2
    • 1
    • 1
    • 1
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    This Amphiregulin antibody is un-conjugated
    应用范围
    • 26
    • 14
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    • 7
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    产品特性
    Rabbit Polyclonal antibody to Amphiregulin (amphiregulin)
    Amphiregulin antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human Amphiregulin. The exact sequence is proprietary.
    亚型
    IgG
    Top Product
    Discover our top product AREG Primary Antibody
  • 应用备注
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: AREG-transfected 293T

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.17 mg/mL
    缓冲液
    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Yaojia Cheng, Lu, Shi, Zhou, Rong, Li, Wang, Liu: "Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG." in: International journal of molecular medicine, Vol. 45, Issue 4, pp. 1163-1175, (2020) (PubMed).

    Khelwatty, Essapen, Bagwan, Green, Seddon, Modjtahedi: "The impact of co-expression of wild-type EGFR and its ligands determined by immunohistochemistry for response to treatment with cetuximab in patients with metastatic colorectal cancer." in: Oncotarget, Vol. 8, Issue 5, pp. 7666-7677, (2018) (PubMed).

  • 抗原
    Amphiregulin (AREG)
    别名
    amphiregulin (AREG 产品)
    别名
    AR antibody, CRDGF antibody, SDGF antibody, Sdgf antibody, AREG antibody, AREGB antibody, AREG/SDGF antibody, amphiregulin antibody, AREG antibody, Areg antibody
    背景
    The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.

    Cellular Localization: Membrane
    分子量
    28 kDa
    基因ID
    374
    UniProt
    P15514
    途径
    RTK signaling, EGFR Signaling Pathway
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