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PARP1 抗体

KO Validated PARP1 适用: 人 WB, IP, IF, IHC (p), ICC, ChIP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2854798
发货至: 中国
  • 抗原 See all PARP1 抗体
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    适用
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    宿主
    • 220
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    克隆类型
    • 207
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    多克隆
    标记
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    This PARP1 antibody is un-conjugated
    应用范围
    • 160
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    Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Rabbit Polyclonal antibody to PARP (poly (ADP-ribose) polymerase 1)
    PARP antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    质量等级
    KO Validated
    免疫原
    Recombinant protein encompassing a sequence within the center region of human PARP1. The exact sequence is proprietary.
    亚型
    IgG
  • 应用备注
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    说明

    Positive Control: HCT116 (30uM cisplatin treatment for 24hr) , PC-12 , Rat2 , 293T , A431 , HeLa , HepG2

    Validation: Comparison, KO/KD, Orthogonal, Overexpression

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.3 mg/mL
    缓冲液
    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Takino, Sato, Nagamine, Hori: "The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells." in: Scientific reports, Vol. 9, Issue 1, pp. 16717, (2019) (PubMed).

    Bera, Chiu, Huang, Liang, Lee, Shih: "Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells." in: Neoplasia (New York, N.Y.), Vol. 20, Issue 11, pp. 1106-1120, (2019) (PubMed).

    Dominguez, Maddelein, Pucelle, Nicaise, Maurage, Duyckaerts, Cuvillier, Delisle: "Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain." in: Acta neuropathologica communications, Vol. 6, Issue 1, pp. 25, (2019) (PubMed).

    Li, Chen, Chen, Yen, Fang, Tsai, Chang, Shen, Huang, Chuu, Chang, Hsiung, Jiang: "Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma." in: Scientific reports, Vol. 7, Issue 1, pp. 11893, (2019) (PubMed).

    Chakraborty, Tapryal, Venkova, Horikoshi, Pandita, Sarker, Sarkar, Pandita, Hazra: "Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes." in: Nature communications, Vol. 7, pp. 13049, (2018) (PubMed).

    Liang, Shi, Yang, Qiu, Lin, Qi, Li, Zhao, Liu: "Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells." in: British journal of cancer, Vol. 116, Issue 7, pp. 903-911, (2017) (PubMed).

    Xu, Wu, Zheng, Yu, Yang, Yao, Zhou, Ching, Lau: "Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells." in: Oncotarget, Vol. 7, Issue 5, pp. 6146-58, (2017) (PubMed).

  • 抗原
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    别名
    poly(ADP-ribose) polymerase 1 (PARP1 产品)
    别名
    ADPRT antibody, ADPRT 1 antibody, ADPRT1 antibody, ARTD1 antibody, PARP antibody, PARP-1 antibody, PPOL antibody, pADPRT-1 antibody, Adprt antibody, Parp-1 antibody, 5830444G22Rik antibody, AI893648 antibody, Adprp antibody, Adprt1 antibody, C80510 antibody, parp-1 antibody, sPARP-1 antibody, BEST:LD21673 antibody, CG17685 antibody, CG17696 antibody, CG17718 antibody, CG40411 antibody, D.PARP antibody, Dm.pARTa antibody, Dmel\\CG40411 antibody, LD21673.3prime antibody, PARP1 antibody, dPARP antibody, parp antibody, adprt1 antibody, padprt-1 antibody, ppol antibody, si:dkey-206f10.3 antibody, wu:fc60f12 antibody, zgc:110092 antibody, poly(ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase family, member 1 antibody, Poly-(ADP-ribose) polymerase antibody, poly(ADP-ribose) polymerase 1 L homeolog antibody, PARP1 antibody, Parp1 antibody, Parp antibody, parp1.L antibody, parp1 antibody
    背景
    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

    Cellular Localization: Nucleus
    分子量
    113 kDa
    基因ID
    142
    UniProt
    P09874
    途径
    Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
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