(11 references)-
- 抗原
- pADPR
- 适用
- 所有种类
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宿主
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小鸡
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
- 产品特性
- Recognizes DNA-damage and apoptosis related poly-ADP ribosylated proteins and poly (ADP-ribose) polymer
- 纯化方法
- Immunofractionation
- 免疫原
- poly(ADP-ribose)
- 亚型
- IgY
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anti-pADPR antibody
适用: 所有种类 IHC, ELISA, WB, IP 宿主: 小鼠 Monoclonal 10H unconjugated
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- 应用备注
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WB 1 µg/mL,
IH 1 µg/mL - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS, pH 7.4 with 0,05 % sodium azides
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Stable for 1 year from date of shipment when stored at -20 °C or -70 °C. Stable for at least 1 month at 4 °C.
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: "A systematic analysis of the PARP protein family identifies new functions critical for cell physiology." in: Nature communications, Vol. 4, pp. 2240, (2013) (PubMed).
: "Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase." in: The Biochemical journal, Vol. 402, Issue 2, pp. 279-90, (2007) (PubMed).
: "Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure." in: The Journal of pharmacology and experimental therapeutics, Vol. 312, Issue 3, pp. 891-8, (2005) (PubMed).
: "Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 84, Issue 1, pp. 201-8, (2005) (PubMed).
: "Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function." in: Nature cell biology, Vol. 7, Issue 11, pp. 1133-9, (2005) (PubMed).
: "Poly(ADP-ribose) is required for spindle assembly and structure." in: Nature, Vol. 432, Issue 7017, pp. 645-9, (2004) (PubMed).
: "Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation." in: Molecular medicine (Cambridge, Mass.), Vol. 10, Issue 1-6, pp. 28-35, (2004) (PubMed).
: "Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor." in: The Journal of pharmacology and experimental therapeutics, Vol. 310, Issue 2, pp. 498-504, (2004) (PubMed).
: "Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass." in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 25, Issue 5, pp. 825-32, (2004) (PubMed).
: "Mesenteric injury after cardiopulmonary bypass: role of poly(adenosine 5'-diphosphate-ribose) polymerase." in: Critical care medicine, Vol. 32, Issue 12, pp. 2392-7, (2004) (PubMed).
: "Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications." in: Diabetes, Vol. 54, Issue 1, pp. 234-42, (2004) (PubMed).
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: "A systematic analysis of the PARP protein family identifies new functions critical for cell physiology." in: Nature communications, Vol. 4, pp. 2240, (2013) (PubMed).
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- 抗原
- pADPR
- 背景
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Synonyms: poly(ADP-ribose)
Poly(ADP-ribose) or pADPr is a polymer synthesized by a class of enzymes named poly(ADP-ribose) polymerase (PARP). Using NAD+ as substrate, PARP catalyzes the formation of the polymer pADPr, with chain lengths ranging from 2 to 300 residues, containing approximately 2 % branching in the chain. pADPr becomes attached to nuclear proteins, and to PARP itself (automodification).
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